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papi papi [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33401, updated on 18-Sep-2024

Summary

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Official Symbol
papiprovided by FlyBase
Official Full Name
papiprovided by FlyBase
Primary source
FLYBASE:FBgn0031401
Locus tag
Dmel_CG7082
See related
AllianceGenome:FB:FBgn0031401
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg7082; CG7082; Dmel\CG7082; Papi; PAPI
Summary
Enables protein N-terminus binding activity. Involved in negative regulation of transposon integration and positive regulation of protein localization. Located in P granule. Part of protein-containing complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; early extended germ band embryo; embryonic/larval midgut; and presumptive embryonic/larval digestive system. Used to study azoospermia. Orthologous to human TDRKH (tudor and KH domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See papi in Genome Data Viewer
Location:
22D4-22D4; 2-5 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2220748..2225544)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2220748..2225544)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene missing oocyte Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44114 Neighboring gene sauron

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi. Zhang Y, et al. Proc Natl Acad Sci U S A, 2018 Mar 27. PMID 29531043, Free PMC Article
  2. Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila. Ku HY, et al. PLoS Genet, 2016 Jan. PMID 26808625, Free PMC Article
  3. Genetic and mechanistic diversity of piRNA 3'-end formation. Hayashi R, et al. Nature, 2016 Nov 24. PMID 27851737, Free PMC Article
  4. Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity. Darricarrère N, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297219, Free PMC Article
  5. A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals. Gainetdinov I, et al. Mol Cell, 2018 Sep 6. PMID 30193099, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P granule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary piRNA processing IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in retrotransposon silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
papi
Names
CG7082-PA
CG7082-PB
CG7082-PC
CG7082-PD
papi-PA
papi-PB
papi-PC
papi-PD
partner of PIWIs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2220748..2225544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164461.2 → NP_722773.1  papi, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722773.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQ91
    Related
    FBpp0077508
    Conserved Domains (3) summary
    cd00105
    Location:68 → 127
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:138 → 201
    KH_1; KH domain
    pfam00567
    Location:257 → 386
    TUDOR; Tudor domain

  2. NM_134813.3 → NP_608657.1  papi, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608657.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQ91
    Related
    FBpp0077509
    Conserved Domains (3) summary
    cd00105
    Location:68 → 127
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:138 → 201
    KH_1; KH domain
    pfam00567
    Location:257 → 386
    TUDOR; Tudor domain

  3. NM_164462.2 → NP_722774.1  papi, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722774.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQ91
    Related
    FBpp0077510
    Conserved Domains (3) summary
    cd00105
    Location:68 → 127
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:138 → 201
    KH_1; KH domain
    pfam00567
    Location:257 → 386
    TUDOR; Tudor domain

  4. NM_164463.2 → NP_722775.1  papi, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_722775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VQ91
    Related
    FBpp0077511
    Conserved Domains (3) summary
    cd00105
    Location:68 → 127
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam00013
    Location:138 → 201
    KH_1; KH domain
    pfam00567
    Location:257 → 386
    TUDOR; Tudor domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VQ91.1 Q9VQ91

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