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ptpn11a protein tyrosine phosphatase non-receptor type 11a [ Danio rerio (zebrafish) ]

Gene ID: 333979, updated on 17-Nov-2020

Summary

Official Symbol
ptpn11aprovided by ZNC
Official Full Name
protein tyrosine phosphatase non-receptor type 11aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5911
See related
Ensembl:ENSDARG00000020334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sh; ptp; shp2; ptpn11; fa14b09; wu:fi24f0; zgc:55388; wu:fa14b09; wu:fi24f03
Orthologs

Genomic context

See ptpn11a in Genome Data Viewer
Location:
chromosome: 10
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (3428194..3450852)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (3427890..3450548)
103 previous assembly Zv9 (GCF_000002035.4) 10 NC_007121.5 (3435696..3458354)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene rabphilin 3A homolog (mouse), a Neighboring gene phospholipase A2 group III

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
convergent extension involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
convergent extension involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
embryonic viscerocranium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic viscerocranium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart jogging IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 11
Names
protein tyrosine phosphatase SH-PTP2
protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1)
protein tyrosine phosphatase, non-receptor type 11, a
protein-tyrosine phosphatase SHP-2a
NP_956140.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199846.1NP_956140.1  tyrosine-protein phosphatase non-receptor type 11

    See identical proteins and their annotated locations for NP_956140.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045328
    UniProtKB/TrEMBL
    Q7ZW17
    Related
    ENSDARP00000076040.5, ENSDART00000081599.6
    Conserved Domains (4) summary
    cd09931
    Location:111219
    SH2_C-SH2_SHP_like; C-terminal Src homology 2 (C-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    cd10340
    Location:5103
    SH2_N-SH2_SHP_like; N-terminal Src homology 2 (N-SH2) domain found in SH2 domain Phosphatases (SHP) proteins
    smart00194
    Location:247521
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:277520
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    3428194..3450852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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