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N4bp2 NEDD4 binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 333789, updated on 5-Jan-2023

Summary

Official Symbol
N4bp2provided by MGI
Official Full Name
NEDD4 binding protein 2provided by MGI
Primary source
MGI:MGI:2684414
See related
Ensembl:ENSMUSG00000037795 AllianceGenome:MGI:2684414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B3bp; Gm868; Gm1791; E430014I16
Summary
Predicted to enable ATP binding activity; endonuclease activity; and polydeoxyribonucleotide 5'-hydroxyl-kinase activity. Predicted to act upstream of or within phosphorylation. Located in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human N4BP2 (NEDD4 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.8), limb E14.5 (RPKM 6.3) and 27 other tissues See more
Orthologs
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Genomic context

See N4bp2 in Genome Data Viewer
Location:
5; 5 C3.1
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65909462..65987450)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65760510..65830107)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40309 Neighboring gene ubiquitin-conjugating enzyme E2K Neighboring gene PDS5 cohesin associated factor A Neighboring gene predicted gene, 24399 Neighboring gene predicted gene 5296 Neighboring gene predicted gene 3521 Neighboring gene ras homolog family member H

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NEDD4-binding protein 2
Names
Bcl3 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024917.1NP_001020088.1  NEDD4-binding protein 2

    See identical proteins and their annotated locations for NP_001020088.1

    Status: VALIDATED

    Source sequence(s)
    AK173167, BC054549, CK637074, CX769144
    Consensus CDS
    CCDS19310.1
    UniProtKB/TrEMBL
    F8VQG7, Q69ZK1
    Related
    ENSMUSP00000143807.2, ENSMUST00000201489.4
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65909462..65987450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254611.2XP_030110471.1  NEDD4-binding protein 2 isoform X2

    Conserved Domains (5) summary
    smart00463
    Location:16761758
    SMR; Small MutS-related domain
    COG5099
    Location:172333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16091670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452578
    AAA_33; AAA domain
  2. XM_036165236.1XP_036021129.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain
  3. XM_030254610.2XP_030110470.1  NEDD4-binding protein 2 isoform X2

    Conserved Domains (5) summary
    smart00463
    Location:16761758
    SMR; Small MutS-related domain
    COG5099
    Location:172333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16091670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452578
    AAA_33; AAA domain
  4. XM_006504004.5XP_006504067.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504067.1

    Conserved Domains (5) summary
    smart00463
    Location:17031785
    SMR; Small MutS-related domain
    COG5099
    Location:199360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16361697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479605
    AAA_33; AAA domain
  5. XM_030254615.2XP_030110475.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain
  6. XM_006504003.3XP_006504066.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504066.1

    Conserved Domains (5) summary
    smart00463
    Location:17031785
    SMR; Small MutS-related domain
    COG5099
    Location:199360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16361697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479605
    AAA_33; AAA domain
  7. XM_006504007.4XP_006504070.1  NEDD4-binding protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006504070.1

    UniProtKB/TrEMBL
    F8VQG7
    Related
    ENSMUSP00000084519.4, ENSMUST00000087264.4
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain
  8. XM_006504006.5XP_006504069.1  NEDD4-binding protein 2 isoform X2

    Conserved Domains (5) summary
    smart00463
    Location:16761758
    SMR; Small MutS-related domain
    COG5099
    Location:172333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16091670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452578
    AAA_33; AAA domain
  9. XM_030254614.1XP_030110474.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain
  10. XM_030254609.2XP_030110469.1  NEDD4-binding protein 2 isoform X2

    Conserved Domains (5) summary
    smart00463
    Location:16761758
    SMR; Small MutS-related domain
    COG5099
    Location:172333
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:4787
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16091670
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:452578
    AAA_33; AAA domain
  11. XM_030254612.1XP_030110472.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain
  12. XM_030254613.1XP_030110473.1  NEDD4-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    F8VQG7
    Conserved Domains (4) summary
    smart00463
    Location:15961678
    SMR; Small MutS-related domain
    COG5099
    Location:92253
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    pfam08590
    Location:15291590
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:372498
    AAA_33; AAA domain
  13. XM_011240752.3XP_011239054.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011239054.1

    Conserved Domains (5) summary
    smart00463
    Location:17031785
    SMR; Small MutS-related domain
    COG5099
    Location:199360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16361697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479605
    AAA_33; AAA domain
  14. XM_006504005.4XP_006504068.1  NEDD4-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504068.1

    Conserved Domains (5) summary
    smart00463
    Location:17031785
    SMR; Small MutS-related domain
    COG5099
    Location:199360
    COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    cd14365
    Location:74114
    CUE_N4BP2; CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins
    pfam08590
    Location:16361697
    DUF1771; Domain of unknown function (DUF1771)
    pfam13671
    Location:479605
    AAA_33; AAA domain
  15. XM_017320937.2XP_017176426.1  NEDD4-binding protein 2 isoform X4

    Conserved Domains (2) summary
    smart00463
    Location:11051187
    SMR; Small MutS-related domain
    pfam08590
    Location:10381099
    DUF1771; Domain of unknown function (DUF1771)