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NLaz Neural Lazarillo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33324, updated on 8-Apr-2026
Official Symbol
NLazprovided by FlyBase
Official Full Name
Neural Lazarilloprovided by FlyBase
Primary source
FLYBASE:FBgn0053126
Locus tag
Dmel_CG33126
See related
AllianceGenome:FB:FBgn0053126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE67583; CG16933; CG33126; CT33980; Dmel\CG33126; DNLaz; nlaz; Nlaz
Summary
Predicted to enable pigment binding activity. Involved in several processes, including carbohydrate homeostasis; determination of adult lifespan; and triglyceride homeostasis. Located in extracellular space. Is expressed in several structures, including adult head; amnioserosa; ganglia; gut section; and larval CNS neuron. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human APOD (apolipoprotein D). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See NLaz in Genome Data Viewer
Location:
22A1-22A1; 2-3 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (1359837..1361821, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (1359837..1361821, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44898 Neighboring gene antisense RNA:CR44897 Neighboring gene roundabout 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo. Pasco MY, et al. PLoS One, 2012. PMID 22567167, Free PMC Article
  2. Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. Ruiz M, et al. Exp Gerontol, 2011 Jul. PMID 21376794
  3. Grasshopper Lazarillo, a GPI-anchored Lipocalin, increases Drosophila longevity and stress resistance, and functionally replaces its secreted homolog NLaz. Ruiz M, et al. Insect Biochem Mol Biol, 2012 Oct. PMID 22846641
  4. Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation. Ruiz M, et al. FEBS J, 2013 Aug. PMID 23777559
  5. Apolipoprotein D in Oxidative Stress and Inflammation. Fyfe-Desmarais G, et al. Antioxidants (Basel), 2023 Apr 28. PMID 37237893, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that NLazWT has stronger cell survival-promoting activity than NLazL130R under oxidative stress in a cell culture-based assay.
    Title: Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila.
  2. Data suggest that NLaz binds lyophilic ligands: retinoic acid, retinol, fatty acids, sphingomyelin, ergosterol, 7-tricosene. NLaz successfully delivers retinoic acid to immature neuronal cell line resulting in neurogenesis (i.e., neurite formation).
    Title: Lipid-binding properties of human ApoD and Lazarillo-related lipocalins: functional implications for cell differentiation.
  3. alters lifespan in both sexes
    Title: Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.
  4. NLaz is transcriptionally regulated by JNK signaling and is required for JNK-mediated stress.
    Title: Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables pigment binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insemination HEP PubMed 
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to reactive oxygen species IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to stress IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
neural lazarillo
Names
CG33126-PA
CG33126-PB
CG33126-PC
NLaz-PA
NLaz-PB
NLaz-PC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    1359837..1361821 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298631.1 → NP_001285560.1  neural lazarillo, isoform C

    See identical proteins and their annotated locations for NP_001285560.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXR1, Q9NAZ4, Q9VQ05
    Conserved Domains (1) summary
    cl21528
    Location:36 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  2. NM_175946.2 → NP_787960.1  neural lazarillo, isoform A

    See identical proteins and their annotated locations for NP_787960.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXR1, Q9NAZ4, Q9VQ05
    Related
    FBpp0077607
    Conserved Domains (1) summary
    cl21528
    Location:36 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

  3. NM_001272938.2 → NP_001259867.1  neural lazarillo, isoform B

    See identical proteins and their annotated locations for NP_001259867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBN2, Q9NAZ4
    Conserved Domains (1) summary
    cl21528
    Location:36 → 164
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBN2 M9PBN2
Q8SXR1 Q8SXR1
Q9NAZ4 Q9NAZ4

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