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HSP90AB3P heat shock protein 90 alpha family class B member 3, pseudogene [ Homo sapiens (human) ]

Gene ID: 3327, updated on 5-Jul-2025
Official Symbol
HSP90AB3Pprovided by HGNC
Official Full Name
heat shock protein 90 alpha family class B member 3, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:5259
See related
Ensembl:ENSG00000183199 AllianceGenome:HGNC:5259
Gene type
pseudo
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPCP1; HSP90BC
Summary
Predicted to enable ATP binding activity; ATP hydrolysis activity; and unfolded protein binding activity. Predicted to be involved in cellular response to heat; protein folding; and protein stabilization. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
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See HSP90AB3P in Genome Data Viewer
Location:
4q22.1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (87891748..87894288)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (91218175..91220725)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (88812900..88815440)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene IBSP 5' regulatory region Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:88740127-88741326 Neighboring gene integrin binding sialoprotein Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:88786985-88787797 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:88813182-88814381 Neighboring gene Sharpr-MPRA regulatory region 543 Neighboring gene Sharpr-MPRA regulatory region 601 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88842859-88843386 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:88843387-88843913 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:88856983-88857804 Neighboring gene uncharacterized LOC124900730 Neighboring gene SPP1 5' regulatory region Neighboring gene secreted phosphoprotein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Assignment of an intron-containing human heat-shock protein gene (hsp90 beta, HSPCB) to chromosome 6 near TCTE1 (6p21) and two intronless pseudogenes to chromosomes 4 and 15 by polymerase chain reaction amplification from a panel of hybrid cell lines. Durkin AS, et al. Genomics, 1993 Nov. PMID 8288256
  2. The HSP90 family of genes in the human genome: insights into their divergence and evolution. Chen B, et al. Genomics, 2005 Dec. PMID 16269234
  3. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. Lingappa JR, et al. PLoS One, 2011. PMID 22174851, Free PMC Article
  4. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Rivadeneira F, et al. Nat Genet, 2009 Nov. PMID 19801982, Free PMC Article
  5. A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease. Cao Y, et al. EMBO J, 2023 Jul 3. PMID 36896912, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
EBI GWAS Catalog

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Other Names

  • heat shock 90kD protein 1, beta pseudogene 1
  • heat shock 90kDa protein 1, beta pseudogene 1
  • heat shock protein 90Bc
  • heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene
  • heat shock protein 90kDa alpha family class B member 3, pseudogene

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase binding IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables histone deacetylase binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in telomerase holoenzyme complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in ficolin-1-rich granule lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule lumen IEA
Inferred from Electronic Annotation
more info
  

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_003015.4 

    Range
    101..2641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    87891748..87894288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    91218175..91220725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_036694.1: Suppressed sequence

    Description
    NR_036694.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q58FF7.1 GenPept UniProtKB/Swiss-Prot:Q58FF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials