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GABA-B-R3 metabotropic GABA-B receptor subtype 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33248, updated on 8-Apr-2026
Official Symbol
GABA-B-R3provided by FlyBase
Official Full Name
metabotropic GABA-B receptor subtype 3provided by FlyBase
Primary source
FLYBASE:FBgn0031275
Locus tag
Dmel_CG3022
See related
AllianceGenome:FB:FBgn0031275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.13; anon-WO0170980.14; CG3022; D-GABA-B-R3; D-Gaba3; D-GABA[[B]]R3; Dmel\CG3022; GABA B R3; GABA-BR3; GABAb R3; GABAB(R3); GABA[[B]]-R3; GABA[[B]]R3; GB3
Summary
Predicted to enable G protein-coupled GABA receptor activity. Involved in sleep. Predicted to be located in membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in larval brain; larval gnathal ganglion; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See GABA-B-R3 in Genome Data Viewer
Location:
21E2-21E2; 2-1.5 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (749945..762399)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (749945..762399)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Heat shock protein 60B Neighboring gene Excitatory amino acid transporter 2 Neighboring gene long non-coding RNA:CR44614 Neighboring gene uncharacterized protein

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and functional expression of GABA(B) receptors from Drosophila. Mezler M, et al. Eur J Neurosci, 2001 Feb. PMID 11168554
  2. High Throughput Sequencing Identifies MicroRNAs Mediating α-Synuclein Toxicity by Targeting Neuroactive-Ligand Receptor Interaction Pathway in Early Stage of Drosophila Parkinson's Disease Model. Kong Y, et al. PLoS One, 2015. PMID 26361355, Free PMC Article
  3. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. Haynes PR, et al. Elife, 2015 Jan 7. PMID 25564731, Free PMC Article
  4. Divergent evolution in metabotropic glutamate receptors. A new receptor activated by an endogenous ligand different from glutamate in insects. Mitri C, et al. J Biol Chem, 2004 Mar 5. PMID 14660580
  5. Activity-Dependent Remodeling of Drosophila Olfactory Sensory Neuron Brain Innervation during an Early-Life Critical Period. Golovin RM, et al. J Neurosci, 2019 Apr 17. PMID 30755492, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables G protein-coupled GABA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled GABA receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled GABA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of G protein-coupled receptor heterodimeric complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
metabotropic GABA-B receptor subtype 3
Names
CG3022-PA
CG3022-PC
CG3022-PD
CG3022-PE
CG3022-PF
CG3022-PG
CG3022-PH
GABA-B receptor subtype 3
GABA-B-R3-PA
GABA-B-R3-PC
GABA-B-R3-PD
GABA-B-R3-PE
GABA-B-R3-PF
GABA-B-R3-PG
GABA-B-R3-PH

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    749945..762399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164387.2 → NP_722648.2  metabotropic GABA-B receptor subtype 3, isoform E

    See identical proteins and their annotated locations for NP_722648.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPW4, Q9BML5, Q9VPS7
    Conserved Domains (3) summary
    cd06366
    Location:157 → 590
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:633 → 889
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:174 → 568
    ANF_receptor; Receptor family ligand binding region

  2. NM_001298625.1 → NP_001285554.1  metabotropic GABA-B receptor subtype 3, isoform G

    See identical proteins and their annotated locations for NP_001285554.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPW4, Q9BML5, Q9VPS7
    Conserved Domains (3) summary
    cd06366
    Location:157 → 590
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:633 → 889
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:174 → 568
    ANF_receptor; Receptor family ligand binding region

  3. NM_001258897.1 → NP_001245826.1  metabotropic GABA-B receptor subtype 3, isoform D

    See identical proteins and their annotated locations for NP_001245826.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPW4, Q9BML5, Q9VPS7
    Conserved Domains (3) summary
    cd06366
    Location:157 → 590
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:633 → 889
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:174 → 568
    ANF_receptor; Receptor family ligand binding region

  4. NM_001298624.1 → NP_001285553.1  metabotropic GABA-B receptor subtype 3, isoform F

    See identical proteins and their annotated locations for NP_001285553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J488
    Conserved Domains (1) summary
    cd06366
    Location:157 → 345
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

  5. NM_001298623.1 → NP_001285552.1  metabotropic GABA-B receptor subtype 3, isoform H

    See identical proteins and their annotated locations for NP_001285552.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J962
    Conserved Domains (2) summary
    cd06366
    Location:157 → 420
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam01094
    Location:174 → 417
    ANF_receptor; Receptor family ligand binding region

  6. NM_078723.3 → NP_523447.2  metabotropic GABA-B receptor subtype 3, isoform A

    See identical proteins and their annotated locations for NP_523447.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPW4, Q9BML5, Q9VPS7
    Related
    FBpp0077666
    Conserved Domains (3) summary
    cd06366
    Location:157 → 590
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam00003
    Location:633 → 889
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:174 → 568
    ANF_receptor; Receptor family ligand binding region

  7. NM_001169375.1 → NP_001162846.1  metabotropic GABA-B receptor subtype 3, isoform C

    See identical proteins and their annotated locations for NP_001162846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058U9
    Conserved Domains (2) summary
    cd06366
    Location:157 → 590
    PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
    pfam01094
    Location:174 → 568
    ANF_receptor; Receptor family ligand binding region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q058U9 Q058U9
Q8MSP9 Q8MSP9
Q9BML5 Q9BML5
Q9VPS7 Q9VPS7
X2J488 X2J488
X2J962 X2J962

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