U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnk18 potassium channel, subfamily K, member 18 [ Mus musculus (house mouse) ]

Gene ID: 332396, updated on 12-May-2024

Summary

Official Symbol
Kcnk18provided by MGI
Official Full Name
potassium channel, subfamily K, member 18provided by MGI
Primary source
MGI:MGI:2685627
See related
Ensembl:ENSMUSG00000040901 AllianceGenome:MGI:2685627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trik; Gm781; Tresk; Tresk-2
Summary
Enables calcium-activated potassium channel activity. Acts upstream of or within potassium ion transport. Located in plasma membrane. Is expressed in gut; male reproductive gland or organ; and olfactory lobe. Human ortholog(s) of this gene implicated in migraine with aura. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnk18 in Genome Data Viewer
Location:
19 D3; 19 54.63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (59208080..59225802)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (59219648..59237370)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930442E04 gene Neighboring gene ventral anterior homeobox 1 Neighboring gene VISTA enhancer mm447 Neighboring gene solute carrier family 18 (vesicular monoamine), member 2 Neighboring gene PDZ domain containing 8 Neighboring gene ribosomal protein S12, pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium channel subfamily K member 18
Names
2P K ion channel TRESK
TWIK-related individual K+ channel
TWIK-related spinal cord K+ channel
two-pore-domain potassium channel TRESK

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207261.3NP_997144.1  potassium channel subfamily K member 18

    See identical proteins and their annotated locations for NP_997144.1

    Status: VALIDATED

    Source sequence(s)
    AC107710
    Consensus CDS
    CCDS29934.1
    UniProtKB/Swiss-Prot
    Q1LZJ5, Q1LZM8, Q3MI50, Q3MI51, Q6VV64
    Related
    ENSMUSP00000065713.7, ENSMUST00000065204.8
    Conserved Domains (1) summary
    pfam07885
    Location:111166
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    59208080..59225802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)