U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zscan10 zinc finger and SCAN domain containing 10 [ Mus musculus (house mouse) ]

Gene ID: 332221, updated on 8-Dec-2022

Summary

Official Symbol
Zscan10provided by MGI
Official Full Name
zinc finger and SCAN domain containing 10provided by MGI
Primary source
MGI:MGI:3040700
See related
Ensembl:ENSMUSG00000023902 AllianceGenome:MGI:3040700
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp206; Znf206; Zkscan10
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; limb mesenchyme; and nervous system. Orthologous to human ZSCAN10 (zinc finger and SCAN domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 1.9), cerebellum adult (RPKM 0.3) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Zscan10 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23819800..23829993)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23600826..23611019)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330415G19 gene Neighboring gene zinc finger protein 213 Neighboring gene zinc finger protein 13 Neighboring gene calcium binding protein 39-like pseudogene Neighboring gene matrix metallopeptidase 25 Neighboring gene ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell differentiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and SCAN domain-containing protein 10
Names
zinc finger and SCAN domains 10
zinc finger protein 206
zinc finger with KRAB and SCAN domains 10

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033425.4NP_001028597.2  zinc finger and SCAN domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001028597.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CF896527
    Consensus CDS
    CCDS28451.1
    UniProtKB/Swiss-Prot
    Q20D63, Q3URR7
    Related
    ENSMUSP00000093255.3, ENSMUST00000095595.9
    Conserved Domains (6) summary
    cd07936
    Location:39123
    SCAN; SCAN oligomerization domain
    COG5048
    Location:366767
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:639659
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:754776
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:679704
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:592643
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. NM_001289481.1NP_001276410.1  zinc finger and SCAN domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001276410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate in-frame splice sites in the 3' coding region, compared to variant 1. This results in an isoform (2) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
    Consensus CDS
    CCDS70766.1
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000113386.2, ENSMUST00000120967.8
    Conserved Domains (6) summary
    cd07936
    Location:39123
    SCAN; SCAN oligomerization domain
    COG5048
    Location:318735
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:607627
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:722744
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:647672
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:560611
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. NM_001289482.1NP_001276411.1  zinc finger and SCAN domain-containing protein 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the coding region, compared to variant 1. This results in an isoform (3) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CF896527
    Consensus CDS
    CCDS79510.1
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000111171.2, ENSMUST00000115509.8
    Conserved Domains (7) summary
    smart00431
    Location:39147
    SCAN; leucine rich region
    cd07936
    Location:39123
    SCAN; SCAN oligomerization domain
    COG5048
    Location:256657
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:644666
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:569594
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:482533
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. NM_001289483.1NP_001276412.1  zinc finger and SCAN domain-containing protein 10 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate in-frame splice sites in the 5' and 3' coding region and initiates translation at a downstream start codon, compared to variant 1. This results in an isoform (4) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000118987.2, ENSMUST00000129227.8
    Conserved Domains (5) summary
    COG5048
    Location:114531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:403423
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518540
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:443468
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:356407
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  5. NM_001289484.1NP_001276413.1  zinc finger and SCAN domain-containing protein 10 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses alternate in-frame splice sites in the 5' and 3' coding region, compared to variant 1. This results in an isoform (5) that is shorter, compared to isoform 1.
    Source sequence(s)
    AC154766, AK141259, BM933809, BX526901, CD539380, CF896527
    UniProtKB/Swiss-Prot
    Q3URR7
    Related
    ENSMUSP00000120876.2, ENSMUST00000148062.8
    Conserved Domains (6) summary
    cd07936
    Location:39127
    SCAN; SCAN oligomerization domain
    COG5048
    Location:273690
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:562582
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:677699
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:602627
    zf-H2C2_2; Zinc-finger double domain
    cl00195
    Location:515566
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23819800..23829993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)