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Plc21C Phospholipase C at 21C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33204, updated on 4-Jan-2025

Summary

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Official Symbol
Plc21Cprovided by FlyBase
Official Full Name
Phospholipase C at 21Cprovided by FlyBase
Primary source
FLYBASE:FBgn0004611
Locus tag
Dmel_CG4574
See related
AllianceGenome:FB:FBgn0004611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4574; Dmel\CG4574; PLC; plc-21; PLC-21; PLC-21C; plc21; Plc21; plc21c; plc21C; Plc21c; PLC21c; PLC21C; plcbeta21c; Plcbeta21C; PLC[[Beta]]
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including entrainment of circadian clock by photoperiod; flight behavior; and positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; adult optic lobe; ganglia; gland; and head. Used to study obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; myelodysplastic syndrome; and spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to several human genes including PLCB1 (phospholipase C beta 1) and PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Plc21C in Genome Data Viewer
Location:
21B8-21C1; 2-0.7 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (305935..355566)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (305935..355566)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Stress induced phosphoprotein 1 Neighboring gene Pi3K21B Neighboring gene long non-coding RNA:CR43719 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45367 Neighboring gene antisense RNA:CR45366 Neighboring gene Equilibrative nucleoside transporter 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway. Ando T, et al. Cells, 2024 Jun 5. PMID 38891118, Free PMC Article
  2. Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Albert S, et al. Gene, 1997 Oct 1. PMID 9370280
  3. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. Ma HW, et al. J Biol Chem, 1993 Sep 25. PMID 8397190
  4. Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster. Kim S, et al. J Biol Chem, 1995 Jun 16. PMID 7540168
  5. A Drosophila phospholipase C gene that is expressed in the central nervous system. Shortridge RD, et al. J Biol Chem, 1991 Jul 5. PMID 2061323

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
    Title: Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
  2. Galphaq, Ggamma1 and Plc21C are anti-obesity genes and Akh employs the Galphaq/Ggamma1/Plc21C module of iCa(2+) control to regulate lipid mobilization in adult Drosophila.
    Title: Gαq, Gγ1 and Plc21C control Drosophila body fat storage.
  3. Disruption of PLCb4 function completely blocked light-dependent modulation of Shab currents in Drosophila photoreceptors.
    Title: Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors.
  4. Reduced odor responses from antennal neurons of phospholipase Cbeta mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
    Title: Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
  5. These results are consistent with a model in which phosphatidylinositol 4,5-bisphosphate hydrolysis acts via Ca2+ to activate myosin via MLCK and thereby control actin dynamics during constriction of the contractile ring.
    Title: Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in entrainment of circadian clock by photoperiod IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in flight behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuromuscular synaptic transmission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipase C at 21C
Names
CG4574-PA
CG4574-PB
CG4574-PC
CG4574-PD
CG4574-PG
CG4574-PH
Plc21C-PA
Plc21C-PB
Plc21C-PC
Plc21C-PD
Plc21C-PG
Plc21C-PH
phospholipase C
phospholipase C 21C
phospholipase c at 21c
NP_001259818.1
NP_476851.2
NP_476852.1
NP_995604.2
NP_995605.1
NP_995606.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    305935..355566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_205884.3 → NP_995606.1  phospholipase C at 21C, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995606.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25455
    Conserved Domains (5) summary
    cd00275
    Location:736 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:317 → 702
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:213 → 850
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:20 → 145
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:225 → 317
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. NM_057504.5 → NP_476852.1  phospholipase C at 21C, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476852.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25455
    Related
    FBpp0077710
    Conserved Domains (5) summary
    cd00275
    Location:736 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:317 → 702
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:213 → 850
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:20 → 145
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:225 → 317
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  3. NM_001272889.1 → NP_001259818.1  phospholipase C at 21C, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259818.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25455
    Conserved Domains (4) summary
    cd00275
    Location:675 → 794
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:299 → 641
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:20 → 145
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:225 → 299
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  4. NM_205883.2 → NP_995605.1  phospholipase C at 21C, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995605.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZX5, M9PC05, P25455, Q0E8V1, Q7KTZ7, Q961D5, Q9VPN9
    Conserved Domains (5) summary
    cd00275
    Location:736 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:317 → 702
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:213 → 850
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:20 → 145
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:225 → 317
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  5. NM_057503.5 → NP_476851.2  phospholipase C at 21C, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476851.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25455
    Related
    FBpp0077711
    Conserved Domains (5) summary
    cd00275
    Location:736 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:317 → 702
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:213 → 850
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:20 → 145
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:225 → 317
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  6. NM_205882.2 → NP_995604.2  phospholipase C at 21C, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995604.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25455
    Conserved Domains (5) summary
    cd00275
    Location:736 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:317 → 702
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    PLN02222
    Location:213 → 850
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:20 → 145
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:225 → 317
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25455.3 P25455

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