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HSP90AA1 heat shock protein 90 alpha family class A member 1 [ Homo sapiens (human) ]

Gene ID: 3320, updated on 14-Jun-2020

Summary

Official Symbol
HSP90AA1provided by HGNC
Official Full Name
heat shock protein 90 alpha family class A member 1provided by HGNC
Primary source
HGNC:HGNC:5253
See related
Ensembl:ENSG00000080824 MIM:140571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; Hsp103; HSPCAL1; HSPCAL4; HEL-S-65p
Summary
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in brain (RPKM 360.6), testis (RPKM 312.5) and 25 other tissues See more
Orthologs

Genomic context

See HSP90AA1 in Genome Data Viewer
Location:
14q32.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (102080742..102139749, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (102547075..102606086, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 1 heavy chain 1 Neighboring gene uncharacterized LOC107984661 Neighboring gene RNA, 7SL, cytoplasmic 472, pseudogene Neighboring gene WD repeat domain 20 Neighboring gene uncharacterized LOC105370677 Neighboring gene MOK protein kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Gag-Pol gag-pol HSP90 is incorporated into HIV-1 GagPol virus-like particles PubMed
Nef nef Microvesicles, which contaminate purified HIV-1 inocula due to similar size and density, contain viral protein Nef and cellular proteins HSP90alpha and HSP90beta that are capable of potent stimulation of dendritic cells maturation and ICAM-1 expression PubMed
Pr55(Gag) gag HSP90 is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat Hyperthermia (39.5C) increases expression of HSP90 protein in CD4+ T cells, which enhances HIV-1 Tat-mediated transactivation of the LTR. Hyperthermia also increases single-cycle HIV-1 infection PubMed
tat HIV-1 Tat downregulates the expression of HSP90 in CD4+ T cells, which may contribute to the impairment of hTERT stability and activation in Tat exposed cells PubMed
tat Hsp90 chaperone activity is required for HIV-1 Tat transport through the endosome membrane PubMed
tat Upregulation of actin, heat shock protein 90 and mitochondrial single-stranded DNA binding protein, and downregulation of lactate dehydrogenase are identified in human astrocytes expressing Tat PubMed
tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
Vif vif HIV-1 Vif interacts with HSP90AA1; interaction predicted to be relevant in protein folding and/or macromolecular structure assembly PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1) at amino acid residues 473-474 and 491-492 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31884

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
MHC class II protein complex binding HDA PubMed 
RNA binding HDA PubMed 
TPR domain binding IDA
Inferred from Direct Assay
more info
PubMed 
TPR domain binding TAS
Traceable Author Statement
more info
PubMed 
disordered domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nitric-oxide synthase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to heat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system neuron axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
chaperone-mediated autophagy TAS
Traceable Author Statement
more info
PubMed 
chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial transport TAS
Traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cellular protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of nitric oxide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tau-protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of telomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein refolding TAS
Traceable Author Statement
more info
PubMed 
protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein stabilization TAS
Traceable Author Statement
more info
 
protein unfolding NAS
Non-traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of nitric-oxide synthase activity TAS
Traceable Author Statement
more info
 
regulation of protein complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
response to antibiotic ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cold ISS
Inferred from Sequence or Structural Similarity
more info
 
response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
response to unfolded protein NAS
Non-traceable Author Statement
more info
PubMed 
telomerase holoenzyme complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
telomere maintenance via telomerase IDA
Inferred from Direct Assay
more info
PubMed 
vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axonal growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
lysosomal lumen TAS
Traceable Author Statement
more info
PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
heat shock protein HSP 90-alpha
Names
HSP 86
LPS-associated protein 2
epididymis luminal secretory protein 52
epididymis secretory sperm binding protein Li 65p
heat shock 86 kDa
heat shock 90kD protein 1, alpha
heat shock 90kD protein 1, alpha-like 4
heat shock 90kD protein, alpha-like 4
heat shock 90kDa protein 1, alpha
heat shock protein 90kDa alpha (cytosolic), class A member 1
heat shock protein 90kDa alpha family class A member 1
lipopolysaccharide-associated protein 2
renal carcinoma antigen NY-REN-38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017963.3NP_001017963.2  heat shock protein HSP 90-alpha isoform 1

    See identical proteins and their annotated locations for NP_001017963.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI250920, AJ890083, BX248761, DA237149
    Consensus CDS
    CCDS32160.1
    UniProtKB/Swiss-Prot
    P07900
    UniProtKB/TrEMBL
    Q86SX1
    Related
    ENSP00000335153.7, ENST00000334701.11
    Conserved Domains (3) summary
    smart00387
    Location:162313
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:140854
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:318844
    HSP90; Hsp90 protein
  2. NM_005348.4NP_005339.3  heat shock protein HSP 90-alpha isoform 2

    See identical proteins and their annotated locations for NP_005339.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI250920, AJ890083, DC303876
    Consensus CDS
    CCDS9967.1
    UniProtKB/Swiss-Prot
    P07900
    UniProtKB/TrEMBL
    K9JA46
    Related
    ENSP00000216281.7, ENST00000216281.12
    Conserved Domains (1) summary
    cl27733
    Location:18732
    HSP90; Hsp90 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    102080742..102139749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536718.2XP_011535020.1  heat shock protein HSP 90-alpha isoform X1

    Conserved Domains (3) summary
    smart00387
    Location:161312
    HATPase_c; Histidine kinase-like ATPases
    PTZ00272
    Location:139853
    PTZ00272; heat shock protein 83 kDa (Hsp83); Provisional
    pfam00183
    Location:317843
    HSP90; Hsp90 protein
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