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BIRC5 baculoviral IAP repeat containing 5 [ Homo sapiens (human) ]

Gene ID: 332, updated on 2-Aug-2021

Summary

Official Symbol
BIRC5provided by HGNC
Official Full Name
baculoviral IAP repeat containing 5provided by HGNC
Primary source
HGNC:HGNC:593
See related
Ensembl:ENSG00000089685 MIM:603352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
API4; EPR-1
Summary
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Expression
Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues See more
Orthologs
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Genomic context

See BIRC5 in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (78214253..78225635)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76210334..76221716)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985050 Neighboring gene thymidine kinase 1 Neighboring gene arylformamidase Neighboring gene transmembrane protein 235 Neighboring gene uncharacterized LOC105371910 Neighboring gene threonine aldolase 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of behavioral disinhibition.
GeneReviews: Not available
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
GeneReviews: Not available
Genome-wide association study of chronic periodontitis in a general German population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates survivin expression by transactivating the survivin promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of chromosome passenger complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 5
Names
apoptosis inhibitor 4
apoptosis inhibitor survivin
survivin variant 3 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029069.1 RefSeqGene

    Range
    5058..16440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001012270.2NP_001012270.1  baculoviral IAP repeat-containing protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001012270.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as survivin-deltaEx3, lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AI800528, AL519719, AL547142, BC008718, BG178974, BI254058, BI520186, BM476145
    Consensus CDS
    CCDS32751.1
    UniProtKB/Swiss-Prot
    O15392
    Related
    ENSP00000364086.1, ENST00000374948.6
    Conserved Domains (1) summary
    pfam00653
    Location:1876
    BIR; Inhibitor of Apoptosis domain
  2. NM_001012271.2NP_001012271.1  baculoviral IAP repeat-containing protein 5 isoform 3

    See identical proteins and their annotated locations for NP_001012271.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as survivin-2B, includes an alternate in-frame segment, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct sequence when it is compared to isoform 1.
    Source sequence(s)
    AB028869, AI800528, AL519719, BC008718, BE537971, BG759111, BI254058, BI520186, BQ687404, CB112371
    Consensus CDS
    CCDS32752.1
    UniProtKB/Swiss-Prot
    O15392
    UniProtKB/TrEMBL
    H3BLT4
    Related
    ENSP00000301633.3, ENST00000301633.8
    Conserved Domains (1) summary
    pfam00653
    Location:18110
    BIR; Inhibitor of Apoptosis domain
  3. NM_001168.3NP_001159.2  baculoviral IAP repeat-containing protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001159.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the most frequently occurring transcript and it encodes isoform 1.
    Source sequence(s)
    AI800528, AL519719, BC008718, BC034148, BG759111, BI254058, BI520186
    Consensus CDS
    CCDS11755.1
    UniProtKB/Swiss-Prot
    O15392
    UniProtKB/TrEMBL
    A0A0B4J1S3
    Related
    ENSP00000324180.4, ENST00000350051.8
    Conserved Domains (1) summary
    pfam00653
    Location:1887
    BIR; Inhibitor of Apoptosis domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    78214253..78225635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_934452.3 RNA Sequence

  2. XR_243654.5 RNA Sequence

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