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Bend3 BEN domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 331623, updated on 26-Sep-2022

Summary

Official Symbol
Bend3provided by MGI
Official Full Name
BEN domain containing 3provided by MGI
Primary source
MGI:MGI:2677212
See related
Ensembl:ENSMUSG00000038214 AllianceGenome:MGI:2677212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1553
Summary
Predicted to enable rDNA binding activity. Predicted to be involved in several processes, including histone modification; negative regulation of macromolecule metabolic process; and protein homooligomerization. Predicted to act upstream of or within chromatin organization. Predicted to be located in heterochromatin; nucleolus; and nucleoplasm. Orthologous to human BEND3 (BEN domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.0), limb E14.5 (RPKM 2.1) and 28 other tissues See more
Orthologs
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Genomic context

See Bend3 in Genome Data Viewer
Location:
10; 10 B2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (43355130..43391413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (43479134..43515417)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 2 Neighboring gene ribosomal protein S19, pseudogene 11 Neighboring gene ribosomal protein L41 pseudogene Neighboring gene predicted gene, 47889 Neighboring gene presequence translocase associated motor 16 like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables rDNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables rDNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-K27 trimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3-K4 trimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H3-K9 trimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H4-K20 trimethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rDNA heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BEN domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359600.1NP_001346529.1  BEN domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AK122525, AK143099, BY732040
    Consensus CDS
    CCDS35892.1
    UniProtKB/Swiss-Prot
    Q80TC0
    UniProtKB/TrEMBL
    A0A8C6IGD4
    Conserved Domains (1) summary
    smart01025
    Location:734813
    BEN; The BEN domain is found in diverse animal proteins
  2. NM_001359601.1NP_001346530.1  BEN domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AC121926, AK122525, AK143099, BY732040
    Consensus CDS
    CCDS35892.1
    UniProtKB/Swiss-Prot
    Q80TC0
    UniProtKB/TrEMBL
    A0A8C6IGD4
    Conserved Domains (1) summary
    smart01025
    Location:734813
    BEN; The BEN domain is found in diverse animal proteins
  3. NM_199028.2NP_950193.1  BEN domain-containing protein 3

    See identical proteins and their annotated locations for NP_950193.1

    Status: VALIDATED

    Source sequence(s)
    AK122525, BC060240
    Consensus CDS
    CCDS35892.1
    UniProtKB/Swiss-Prot
    Q6PAL0, Q80TC0
    UniProtKB/TrEMBL
    A0A8C6IGD4
    Related
    ENSMUSP00000127351.2, ENSMUST00000167488.9
    Conserved Domains (1) summary
    smart01025
    Location:734813
    BEN; The BEN domain is found in diverse animal proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    43355130..43391413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245146.2XP_030101006.1  BEN domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q80TC0
    UniProtKB/TrEMBL
    A0A8C6IGD4
    Conserved Domains (1) summary
    smart01025
    Location:734813
    BEN; The BEN domain is found in diverse animal proteins
  2. XM_006512770.5XP_006512833.1  BEN domain-containing protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006512833.1

    UniProtKB/Swiss-Prot
    Q6PAL0, Q80TC0
    UniProtKB/TrEMBL
    A0A8C6IGD4
    Conserved Domains (1) summary
    smart01025
    Location:734813
    BEN; The BEN domain is found in diverse animal proteins
  3. XM_030245147.2XP_030101007.1  BEN domain-containing protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q80TC0
    UniProtKB/TrEMBL
    A0A8C6IGD4
    Conserved Domains (1) summary
    smart01025
    Location:734813
    BEN; The BEN domain is found in diverse animal proteins