U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Il1rapl1 interleukin 1 receptor accessory protein-like 1 [ Mus musculus (house mouse) ]

Gene ID: 331461, updated on 8-Nov-2022

Summary

Official Symbol
Il1rapl1provided by MGI
Official Full Name
interleukin 1 receptor accessory protein-like 1provided by MGI
Primary source
MGI:MGI:2687319
See related
Ensembl:ENSMUSG00000052372 AllianceGenome:MGI:2687319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL1R8; MRX34; OPHN4; IL1RAPL; TIGIRR-2; IL1RAPL-1; C030039N24; 6330532G10Rik
Summary
Enables signaling receptor binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; nervous system development; and positive regulation of nervous system development. Located in cell surface and dendrite. Is expressed in central nervous system; dorsal root ganglion; eye; lung; and trigeminal nerve. Human ortholog(s) of this gene implicated in intellectual disability and non-syndromic X-linked intellectual disability 21. Orthologous to human IL1RAPL1 (interleukin 1 receptor accessory protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 1.3), cortex adult (RPKM 1.1) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Il1rapl1 in Genome Data Viewer
Location:
X; X C1
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (85784543..87159554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (86740937..88115948, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene MAGE family member B7, pseudogene Neighboring gene predicted gene, 39524 Neighboring gene family with sequence similarity 48, member A pseudogene Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene prohibitin pseudogene Neighboring gene nucleophosmin 1 pseudogene Neighboring gene predicted gene 14774 Neighboring gene predicted gene, 25006 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD(P)+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
interleukin-1 receptor accessory protein-like 1
Names
X-linked interleukin-1 receptor accessory protein-like 1
NP_001153875.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160403.2NP_001153875.1  interleukin-1 receptor accessory protein-like 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL627409, AL672059, AL844869, AL844900, AL954362, BX005231
    Consensus CDS
    CCDS53128.1
    UniProtKB/TrEMBL
    B1ASU0, Q0VDP7
    Related
    ENSMUSP00000109599.2, ENSMUST00000113966.8
    Conserved Domains (5) summary
    cd05896
    Location:32135
    Ig1_IL1RAPL-1_like; First immunoglobulin (Ig)-like domain of X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL-1)
    PHA02785
    Location:9334
    PHA02785; IL-beta-binding protein; Provisional
    smart00408
    Location:260341
    IGc2; Immunoglobulin C-2 Type
    pfam01582
    Location:405559
    TIR; TIR domain
    cl11960
    Location:148234
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    85784543..87159554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)