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Slc9a9 solute carrier family 9 (sodium/hydrogen exchanger), member 9 [ Mus musculus (house mouse) ]

Gene ID: 331004, updated on 5-Mar-2024

Summary

Official Symbol
Slc9a9provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 9provided by MGI
Primary source
MGI:MGI:2679732
See related
Ensembl:ENSMUSG00000031129 AllianceGenome:MGI:2679732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nhe9; 9930105B05; 5730527A11Rik
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to act upstream of or within ion transport. Predicted to be located in endosome and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and recycling endosome. Is expressed in several structures, including ear; hemolymphoid system; nervous system; tail somite; and urinary system. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SLC9A9 (solute carrier family 9 member A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 14.4), frontal lobe adult (RPKM 5.0) and 20 other tissues See more
Orthologs
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Genomic context

Location:
9 E3.3; 9 49.22 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (94551945..95112505)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (94669557..95230453)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24923 Neighboring gene predicted gene, 39404 Neighboring gene STARR-seq mESC enhancer starr_24924 Neighboring gene STARR-positive B cell enhancer ABC_E11419 Neighboring gene STARR-seq mESC enhancer starr_24926 Neighboring gene predicted gene, 24178 Neighboring gene microRNA 7656 Neighboring gene STARR-seq mESC enhancer starr_24927 Neighboring gene STARR-seq mESC enhancer starr_24928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:95180411-95180564 Neighboring gene predicted gene, 32018 Neighboring gene STARR-seq mESC enhancer starr_24930 Neighboring gene carbohydrate sulfotransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phagosome maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of intracellular pH IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of intracellular pH ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/hydrogen exchanger 9
Names
Na(+)/H(+) exchanger 9
solute carrier family 9 member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177909.5NP_808577.3  sodium/hydrogen exchanger 9

    See identical proteins and their annotated locations for NP_808577.3

    Status: VALIDATED

    Source sequence(s)
    AC157517, AK037058, BB838484
    Consensus CDS
    CCDS40726.1
    UniProtKB/Swiss-Prot
    Q3U0X0, Q8BZ00
    UniProtKB/TrEMBL
    A8E634, Q3T994, Q499E9
    Related
    ENSMUSP00000033463.10, ENSMUST00000033463.10
    Conserved Domains (1) summary
    pfam00999
    Location:128486
    Na_H_Exchanger; Sodium/hydrogen exchanger family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    94551945..95112505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)