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Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 [ Mus musculus (house mouse) ]

Gene ID: 330953, updated on 21-Apr-2024

Summary

Official Symbol
Hcn4provided by MGI
Official Full Name
hyperpolarization-activated, cyclic nucleotide-gated K+ 4provided by MGI
Primary source
MGI:MGI:1298209
See related
Ensembl:ENSMUSG00000032338 AllianceGenome:MGI:1298209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hcn3; Bcng3
Summary
Enables intracellular cAMP-activated cation channel activity. Acts upstream of or within cation transport; in utero embryonic development; and regulation of heart contraction. Located in axon. Is expressed in eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 4.8), CNS E14 (RPKM 3.6) and 17 other tissues See more
Orthologs
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Genomic context

Location:
9 B; 9 31.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (58730232..58770458)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58822949..58863175)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene REC114 meiotic recombination protein Neighboring gene predicted gene 20620 Neighboring gene STARR-seq mESC enhancer starr_24285 Neighboring gene predicted gene, 21183 Neighboring gene VISTA enhancer mm1997 Neighboring gene STARR-seq mESC enhancer starr_24288 Neighboring gene neogenin Neighboring gene STARR-seq mESC enhancer starr_24289 Neighboring gene STARR-seq mESC enhancer starr_24290 Neighboring gene STARR-seq mESC enhancer starr_24291 Neighboring gene ribosomal protein S10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cAMP-activated cation channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables intracellularly cAMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity involved in SA node cell action potential depolarization ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization during SA node cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of HCN channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of HCN channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Names
brain cyclic nucleotide-gated channel 3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081192.3NP_001074661.1  potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

    See identical proteins and their annotated locations for NP_001074661.1

    Status: VALIDATED

    Source sequence(s)
    AC110530
    Consensus CDS
    CCDS52815.1
    UniProtKB/Swiss-Prot
    O70507
    UniProtKB/TrEMBL
    B2RY58
    Related
    ENSMUSP00000034889.9, ENSMUST00000034889.10
    Conserved Domains (4) summary
    COG0664
    Location:589724
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:595703
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:280525
    Ion_trans; Ion transport protein
    pfam08412
    Location:218260
    Ion_trans_N; Ion transport protein N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    58730232..58770458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)