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Trim67 tripartite motif-containing 67 [ Mus musculus (house mouse) ]

Gene ID: 330863, updated on 5-Mar-2024

Summary

Official Symbol
Trim67provided by MGI
Official Full Name
tripartite motif-containing 67provided by MGI
Primary source
MGI:MGI:3045323
See related
Ensembl:ENSMUSG00000036913 AllianceGenome:MGI:3045323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TNL; D130049O21Rik
Summary
Predicted to enable zinc ion binding activity. Acts upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Located in cytoplasm. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human TRIM67 (tripartite motif containing 67). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 21.5), whole brain E14.5 (RPKM 15.3) and 5 other tissues See more
Orthologs
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Genomic context

Location:
8 E2; 8 72.81 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125519758..125561443)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124791317..124834713)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIB pseudogene Neighboring gene predicted gene, 46059 Neighboring gene RIKEN cDNA 2810004N23 gene Neighboring gene predicted gene 16163 Neighboring gene glyceronephosphate O-acyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
tripartite motif-containing protein 67
Names
TRIM9-like protein TNL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198632.2NP_941034.2  tripartite motif-containing protein 67

    See identical proteins and their annotated locations for NP_941034.2

    Status: VALIDATED

    Source sequence(s)
    AC151736, AK051455, BC094596
    Consensus CDS
    CCDS52704.1
    UniProtKB/Swiss-Prot
    Q505D9
    Related
    ENSMUSP00000130343.2, ENSMUST00000167588.9
    Conserved Domains (5) summary
    smart00502
    Location:334460
    BBC; B-Box C-terminal domain
    cd00063
    Location:513589
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00643
    Location:288327
    zf-B_box; B-box zinc finger
    cd12889
    Location:586757
    SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67
    cl17238
    Location:747
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125519758..125561443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)