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HSPA4 heat shock protein family A (Hsp70) member 4 [ Homo sapiens (human) ]

Gene ID: 3308, updated on 7-Aug-2022


Official Symbol
HSPA4provided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 4provided by HGNC
Primary source
See related
Ensembl:ENSG00000170606 MIM:601113; AllianceGenome:HGNC:5237
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RY; APG-2; HSPH2; hsp70; hsp70RY; HEL-S-5a; HS24/P52
Predicted to enable ATP binding activity. Involved in chaperone-mediated protein complex assembly and protein insertion into mitochondrial outer membrane. Located in cytosol and extracellular exosome. Implicated in Chagas disease. Biomarker of chronic obstructive pulmonary disease; rheumatoid arthritis; type 2 diabetes mellitus; and ulcerative colitis. [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in testis (RPKM 45.7), esophagus (RPKM 33.4) and 25 other tissues See more
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Genomic context

See HSPA4 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (133052013..133106449)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (133571755..133626191)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132387705..132442141)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene zinc finger CCHC-type containing 10 Neighboring gene Sharpr-MPRA regulatory region 5371 Neighboring gene uncharacterized LOC105379178 Neighboring gene ribosomal protein L6 pseudogene 15

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of HSPA4 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
Nef nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
Pr55(Gag) gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
Vif vif HSP70 interacts with both APOBEC3G and HIV-1 Vif, which stabilizes APOBEC3G and blocks Vif-mediated degradation of APOBEC3G. The N-terminal region of Vif involves the interaction with HSP70 PubMed
Vpr vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • MGC131852

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
located_in cytosol IDA
Inferred from Direct Assay
more info
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
heat shock 70 kDa protein 4
epididymis secretory sperm binding protein Li 5a
heat shock 70-related protein APG-2
heat shock 70kD protein 4
heat shock protein, 110 kDa
hsp70 RY

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002154.4NP_002145.3  heat shock 70 kDa protein 4

    See identical proteins and their annotated locations for NP_002145.3

    Status: VALIDATED

    Source sequence(s)
    AB023420, AC113410, BG723797, BQ431980, BU171424, BU686725, CF145856
    Consensus CDS
    P34932, Q9BUK9
    ENSP00000302961.2, ENST00000304858.7
    Conserved Domains (2) summary
    HSPA4_NBD; Nucleotide-binding domain of HSPA4
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060929.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198431.1: Suppressed sequence

    NM_198431.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.