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I-3 Inhibitor-3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33068, updated on 6-Jul-2026
Official Symbol
I-3provided by FlyBase
Official Full Name
Inhibitor-3provided by FlyBase
Primary source
FLYBASE:FBgn0261624
Locus tag
Dmel_CG42707
See related
AllianceGenome:FB:FBgn0261624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11233; CG42707; Dmel\CG42707
Old locus tag
Dmel_CG11233
Summary
Enables protein phosphatase 1 binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be active in nucleus. Orthologous to human PPP1R11 (protein phosphatase 1 regulatory inhibitor subunit 11). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See I-3 in Genome Data Viewer
Location:
19E4-19E4; 1-65 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20881814..20882626, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20752841..20753653, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene shaking B Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Niemann-Pick type C-1b

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873
  2. Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. Blanco E, et al. BMC Dev Biol, 2010 Sep 2. PMID 20813047, Free PMC Article
  3. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  4. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article
  5. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Neely GG, et al. Cell, 2010 Apr 2. PMID 20371351, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Inhibitor-3
Names
CG42707-PB
I-3-PB

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20881814..20882626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167716.3 → NP_728367.3  Inhibitor-3

    See identical proteins and their annotated locations for NP_728367.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0ACM8PZ99, Q6NMV2, Q9VRC5
    Conserved Domains (1) summary
    pfam07491
    Location:60 → 113
    PPI_Ypi1; Protein phosphatase inhibitor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VRC5 Q9VRC5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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