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HSPA2 heat shock protein family A (Hsp70) member 2 [ Homo sapiens (human) ]

Gene ID: 3306, updated on 24-Nov-2020

Summary

Official Symbol
HSPA2provided by HGNC
Official Full Name
heat shock protein family A (Hsp70) member 2provided by HGNC
Primary source
HGNC:HGNC:5235
See related
Ensembl:ENSG00000126803 MIM:140560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSP70-2; HSP70-3
Orthologs

Genomic context

See HSPA2 in Genome Data Viewer
Location:
14q23.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (64535905..64543237)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65007186..65009955)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 25 Neighboring gene A-kinase anchoring protein 5 Neighboring gene uncharacterized LOC102723809 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene nucleoporin 50 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Over expression of hsp70 with a herpes viral amplicon vector protects cultured hippocampal rat neurons from gp120 neurotoxicity PubMed
env The exposure of permissive CD4+ cells to HIV-1 gp120 increases the synthesis and nuclear translocation of 70kDa heat shock protein PubMed
Nef nef Heat shock proteins Hsp40 and Hsp70 interact with HIV-1 Nef and form a complex in cells PubMed
Pr55(Gag) gag Hsp70 is incorporated into HIV-1 virions through an interaction with HIV-1 Gag PubMed
gag Hsp70 co-sediments with HIV-1 capsid protein in sucrose density gradients, providing evidence that it is specifically incorporated into HIV-1 virions through an interaction with HIV-1 Gag proteins PubMed
Tat tat Hsp70 and Hsp90 and Cdc37 regulate the stabilization and folding of CDK9 as well as the assembly of an active CDK9/cyclin T1 complex responsible for P-TEFb-mediated HIV-1 Tat transactivation PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of heat shock 70kDa protein 2 (HSPA2, HSP70-2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
vpr HIV-1 Vpr is required for the inhibitory effect of Hsp70 on viral gene expression and replication PubMed
vpr HIV-1 Vpr competes with Hsp70 for binding to karyopherin alpha PubMed
matrix gag Hsp70 facilitates nuclear import of HIV-1 preintegration complexes by stimulating the binding of HIV-1 Matrix to karyopherin alpha PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
glycolipid binding IEA
Inferred from Electronic Annotation
more info
 
heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tau protein binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
male meiosis I IEA
Inferred from Electronic Annotation
more info
 
male meiotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
negative regulation of inclusion body assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ATPase-coupled calcium transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
response to cold ISS
Inferred from Sequence or Structural Similarity
more info
 
response to heat ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatid development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptonemal complex disassembly IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
CatSper complex ISS
Inferred from Sequence or Structural Similarity
more info
 
blood microparticle HDA PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
male germ cell nucleus IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane HDA PubMed 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptonemal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heat shock-related 70 kDa protein 2
Names
epididymis secretory sperm binding protein
heat shock 70kD protein 2
heat shock 70kDa protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387931.1NP_001374860.1  heat shock-related 70 kDa protein 2

    Status: VALIDATED

    Source sequence(s)
    AL049869
  2. NM_021979.4NP_068814.2  heat shock-related 70 kDa protein 2

    See identical proteins and their annotated locations for NP_068814.2

    Status: VALIDATED

    Source sequence(s)
    BC001752, BC036107, CD300159, CN356507, DB042367
    Consensus CDS
    CCDS9766.1
    UniProtKB/Swiss-Prot
    P54652
    UniProtKB/TrEMBL
    A0A024R6B5
    Related
    ENSP00000247207.6, ENST00000247207.6
    Conserved Domains (1) summary
    PTZ00009
    Location:2615
    PTZ00009; heat shock 70 kDa protein; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    64535905..64543237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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