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Tmem120b transmembrane protein 120B [ Mus musculus (house mouse) ]

Gene ID: 330189, updated on 21-May-2024

Summary

Official Symbol
Tmem120bprovided by MGI
Official Full Name
transmembrane protein 120Bprovided by MGI
Primary source
MGI:MGI:3603158
See related
Ensembl:ENSMUSG00000054434 AllianceGenome:MGI:3603158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in fat cell differentiation and protein heterooligomerization. Located in nuclear inner membrane. Orthologous to human TMEM120B (transmembrane protein 120B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 36.3), mammary gland adult (RPKM 28.5) and 23 other tissues See more
Orthologs
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Genomic context

See Tmem120b in Genome Data Viewer
Location:
5 F; 5 62.75 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123214329..123256272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123076265..123118213)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123489053-123489354 Neighboring gene predicted gene, 42023 Neighboring gene MORN repeat containing 3 Neighboring gene STARR-seq mESC enhancer starr_14309 Neighboring gene STARR-positive B cell enhancer ABC_E6376 Neighboring gene predicted gene 6444 Neighboring gene STARR-seq mESC enhancer starr_14311 Neighboring gene STARR-seq mESC enhancer starr_14312 Neighboring gene STARR-positive B cell enhancer ABC_E10349 Neighboring gene STARR-positive B cell enhancer ABC_E4788 Neighboring gene STARR-positive B cell enhancer ABC_E6377 Neighboring gene STARR-positive B cell enhancer ABC_E1060 Neighboring gene ras homolog family member F (in filopodia) Neighboring gene STARR-positive B cell enhancer ABC_E8079 Neighboring gene STARR-seq mESC enhancer starr_14314 Neighboring gene expressed sequence AI480526 Neighboring gene STARR-positive B cell enhancer ABC_E2763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123591600-123591709 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599408-123599706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599709-123599818 Neighboring gene STARR-positive B cell enhancer ABC_E6378 Neighboring gene SET domain containing 1B Neighboring gene predicted gene, 54284

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in fat cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein heterooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039723.3NP_001034812.1  transmembrane protein 120B isoform 1

    See identical proteins and their annotated locations for NP_001034812.1

    Status: VALIDATED

    Source sequence(s)
    AC158114
    Consensus CDS
    CCDS39262.1
    UniProtKB/Swiss-Prot
    Q14BK6, Q3TA38, Q8R243
    Related
    ENSMUSP00000068551.9, ENSMUST00000067505.15
    Conserved Domains (1) summary
    pfam07851
    Location:9332
    TMPIT; TMPIT-like protein
  2. NM_001420280.1NP_001407209.1  transmembrane protein 120B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158114
    Related
    ENSMUSP00000107246.4, ENSMUST00000111619.10
  3. NM_001420281.1NP_001407210.1  transmembrane protein 120B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC158114

RNA

  1. NR_185159.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158114
  2. NR_185160.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158114

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123214329..123256272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001784711.3 RNA Sequence

    Related
    ENSMUST00000161059.8