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Cxcl3 C-X-C motif chemokine ligand 3 [ Mus musculus (house mouse) ]

Gene ID: 330122, updated on 11-Apr-2024

Summary

Official Symbol
Cxcl3provided by MGI
Official Full Name
C-X-C motif chemokine ligand 3provided by MGI
Primary source
MGI:MGI:3037818
See related
Ensembl:ENSMUSG00000029379 AllianceGenome:MGI:3037818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dcip1; Gm1960
Summary
This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. [provided by RefSeq, May 2013]
Expression
Biased expression in thymus adult (RPKM 1.5), small intestine adult (RPKM 0.7) and 9 other tissues See more
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Genomic context

See Cxcl3 in Genome Data Viewer
Location:
5 E1; 5 44.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90933960..90935952)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90786101..90788093)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13604 Neighboring gene pro-platelet basic protein Neighboring gene platelet factor 4 Neighboring gene C-X-C motif chemokine ligand 15 Neighboring gene STARR-seq mESC enhancer starr_13605 Neighboring gene STARR-seq mESC enhancer starr_13606 Neighboring gene STARR-seq mESC enhancer starr_13607 Neighboring gene C-X-C motif chemokine ligand 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C-X-C motif chemokine 3
Names
chemokine (C-X-C motif) ligand 3
dendritic cell inflammatory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203320.3NP_976065.1  C-X-C motif chemokine 3 precursor

    See identical proteins and their annotated locations for NP_976065.1

    Status: REVIEWED

    Source sequence(s)
    AC105995, AK150314
    Consensus CDS
    CCDS19417.1
    UniProtKB/Swiss-Prot
    Q3UNK9, Q6W5C0
    Related
    ENSMUSP00000031326.9, ENSMUST00000031326.10
    Conserved Domains (1) summary
    cd00273
    Location:3395
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90933960..90935952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)