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Adamts3 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3 [ Mus musculus (house mouse) ]

Gene ID: 330119, updated on 26-Sep-2022

Summary

Official Symbol
Adamts3provided by MGI
Official Full Name
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3provided by MGI
Primary source
MGI:MGI:3045353
See related
Ensembl:ENSMUSG00000043635 AllianceGenome:MGI:3045353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1100001H14Rik; 6330442E02Rik
Summary
Enables peptidase activity. Acts upstream of or within in utero embryonic development and protein processing. Predicted to be located in extracellular space. Predicted to be active in extracellular matrix. Is expressed in embryo; footplate apical ectodermal ridge; and handplate apical ectodermal ridge. Human ortholog(s) of this gene implicated in Hennekam syndrome. Orthologous to human ADAMTS3 (ADAM metallopeptidase with thrombospondin type 1 motif 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 3.5), CNS E18 (RPKM 3.3) and 18 other tissues See more
Orthologs
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Genomic context

See Adamts3 in Genome Data Viewer
Location:
5; 5 E1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (89821700..90031521, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (89673841..89883668, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene neuropeptide FF receptor 2 Neighboring gene predicted gene 7056 Neighboring gene predicted gene, 42162 Neighboring gene predicted gene, 25758 Neighboring gene eukaryotic translation initiation factor 5A-like 3, pseudogene Neighboring gene predicted gene, 35936

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC189989

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 3
Names
ADAM metallopeptidase with thrombospondin type 1 motif, 3
NP_001074870.1
NP_808540.2
XP_017176420.1
XP_036021118.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081401.2NP_001074870.1  A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001074870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC102039, AC102056, AC156611
    Consensus CDS
    CCDS39140.1
    UniProtKB/TrEMBL
    G3X9D2
    Related
    ENSMUSP00000058552.6, ENSMUST00000061427.10
    Conserved Domains (6) summary
    smart00209
    Location:554605
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:256457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:258460
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:66200
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:713827
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10231051
    PLAC; PLAC (protease and lacunin) domain
  2. NM_177872.2NP_808540.2  A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102039, AC102056, AC156611
    Consensus CDS
    CCDS51542.1
    UniProtKB/TrEMBL
    E9Q287
    Related
    ENSMUSP00000132219.2, ENSMUST00000163159.8
    Conserved Domains (6) summary
    smart00209
    Location:554605
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:256457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:258460
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:66200
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:713828
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:10241052
    PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    89821700..90031521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165225.1XP_036021118.1  A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X1

    Conserved Domains (6) summary
    smart00209
    Location:554605
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:256457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:713827
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:43201
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:472540
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:849904
    TSP1_ADAMTS; Thrombospondin type 1 domain
  2. XM_017320931.3XP_017176420.1  A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X2

    Conserved Domains (4) summary
    smart00209
    Location:554605
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:256457
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:43201
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:472540
    ADAM_CR_2; ADAM cysteine-rich domain