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BIRC3 baculoviral IAP repeat containing 3 [ Homo sapiens (human) ]

Gene ID: 330, updated on 13-Mar-2020

Summary

Official Symbol
BIRC3provided by HGNC
Official Full Name
baculoviral IAP repeat containing 3provided by HGNC
Primary source
HGNC:HGNC:591
See related
Ensembl:ENSG00000023445 MIM:601721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AIP1; API2; MIHC; CIAP2; HAIP1; HIAP1; IAP-1; MALT2; RNF49; c-IAP2
Summary
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Expression
Broad expression in lymph node (RPKM 48.6), appendix (RPKM 43.1) and 15 other tissues See more
Orthologs

Genomic context

See BIRC3 in Genome Data Viewer
Location:
11q22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (102317373..102339403)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (102188181..102210134)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 pseudogene 17 Neighboring gene RNA, U6 small nuclear 952, pseudogene Neighboring gene baculoviral IAP repeat containing 2 Neighboring gene transmembrane protein 123

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of baculoviral IAP repeat containing 3 (BIRC3) expression as compared to untreated control PubMed
Tat tat HIV-1 Tat101 upregulates the expression of baculoviral IAP repeat-containing 3 (BIRC3; C-IAP2) in Jurkat cells PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the expression of many proteins, including MIHC, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
Vpr vpr HIV-1 Vpr [TRAF1 and TRAF2 downregulation] is counteracted by BIRC3 (c-IAP-2) in THP-1 cells and monocytes PubMed
vpr Anti-apoptotic proteins BIRC3 (cIAP1) and cIAP2 contribute to macrophage protection against HIV-1 Vpr-induced apoptosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
PubMed 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of necroptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of RIG-I signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
regulation of innate immune response TAS
Traceable Author Statement
more info
PubMed 
regulation of necroptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of necroptotic process TAS
Traceable Author Statement
more info
 
regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 3
Names
IAP homolog C
RING finger protein 49
RING-type E3 ubiquitin transferase BIRC3
TNFR2-TRAF signaling complex protein
TNFR2-TRAF-signaling complex protein 1
apoptosis inhibitor 2
cellular inhibitor of apoptosis 2
inhibitor of apoptosis protein 1
mammalian IAP homolog C
NP_001156.1
NP_892007.1
XP_024304235.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_065365.1 RefSeqGene

    Range
    5001..26920
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001165.5NP_001156.1  baculoviral IAP repeat-containing protein 3

    See identical proteins and their annotated locations for NP_001156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA805622, AA873008, AF070674, AI880555, BC037420, BE907592, BG569841, BU428906, BX415415, BX475964, U37546, U45878
    Consensus CDS
    CCDS8315.1
    UniProtKB/Swiss-Prot
    Q13489
    Related
    ENSP00000263464.3, ENST00000263464.8
    Conserved Domains (4) summary
    smart00238
    Location:254322
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:441530
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    pfam13920
    Location:553598
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21463
    Location:377411
    UBA_like_SF; UBA domain-like superfamily
  2. NM_182962.3NP_892007.1  baculoviral IAP repeat-containing protein 3

    See identical proteins and their annotated locations for NP_892007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA805622, AA873008, AI880555, BC037420, BE907592, BG569841, BX415415, L49432, U45878
    Consensus CDS
    CCDS8315.1
    UniProtKB/Swiss-Prot
    Q13489
    Related
    ENSP00000432907.1, ENST00000532808.5
    Conserved Domains (4) summary
    smart00238
    Location:254322
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:441530
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    pfam13920
    Location:553598
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl21463
    Location:377411
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    102317373..102339403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448467.1XP_024304235.1  baculoviral IAP repeat-containing protein 3 isoform X1

    Conserved Domains (4) summary
    smart00238
    Location:5799
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd08329
    Location:218307
    CARD_BIRC2_BIRC3; Caspase activation and recruitment domain found in Baculoviral IAP repeat-containing proteins, BIRC2 (c-IAP1) and BIRC3 (c-IAP2)
    cd16713
    Location:328381
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    cl21463
    Location:154188
    UBA_like_SF; UBA domain-like superfamily
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