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HSF4 heat shock transcription factor 4 [ Homo sapiens (human) ]

Gene ID: 3299, updated on 8-Jul-2021

Summary

Official Symbol
HSF4provided by HGNC
Official Full Name
heat shock transcription factor 4provided by HGNC
Primary source
HGNC:HGNC:5227
See related
Ensembl:ENSG00000102878 MIM:602438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTM; CTRCT5
Summary
Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 12.6), skin (RPKM 8.5) and 24 other tissues See more
Orthologs
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Genomic context

See HSF4 in Genome Data Viewer
Location:
16q22.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67163761..67169941)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67197664..67203844)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phagosome assembly factor 1 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 Neighboring gene TNFRSF1A associated via death domain Neighboring gene F-box and leucine rich repeat protein 8 Neighboring gene KIAA0895 like Neighboring gene nucleolar protein 3 Neighboring gene exocyst complex component 3 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in histone H3-K9 demethylation IEA
Inferred from Electronic Annotation
more info
 
involved_in lens fiber cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heat shock factor protein 4
Names
HSF 4
HSTF 4
hHSF4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009294.1 RefSeqGene

    Range
    5377..11557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040667.3NP_001035757.1  heat shock factor protein 4 isoform b

    See identical proteins and their annotated locations for NP_001035757.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1, resulting in a longer protein (isoform b). This variant, alternatively referred to as HSF4b, functions as a transcriptional activator of the constitutive expression of heat shock genes.
    Source sequence(s)
    AC074143, AK307211, BC130383, BX348481, CA412687
    Consensus CDS
    CCDS42175.1
    UniProtKB/Swiss-Prot
    Q9ULV5
    UniProtKB/TrEMBL
    A0A024R6X7
    Conserved Domains (3) summary
    smart00415
    Location:16120
    HSF; heat shock factor
    pfam06546
    Location:259443
    Vert_HS_TF; Vertebrate heat shock transcription factor
    pfam15035
    Location:110175
    Rootletin; Ciliary rootlet component, centrosome cohesion
  2. NM_001374674.1NP_001361603.1  heat shock factor protein 4 isoform a

    Status: REVIEWED

    Source sequence(s)
    AK225152, AK293631, D87673
    Related
    ENSP00000463706.1, ENST00000584272.5
    Conserved Domains (2) summary
    smart00415
    Location:16120
    HSF; heat shock factor
    pfam15035
    Location:110175
    Rootletin; Ciliary rootlet component, centrosome cohesion
  3. NM_001374675.1NP_001361604.1  heat shock factor protein 4 isoform b

    Status: REVIEWED

    Source sequence(s)
    AB029348, AC074143, AK293631, D87673
    Related
    ENSP00000430947.2, ENST00000521374.6
    Conserved Domains (3) summary
    smart00415
    Location:16120
    HSF; heat shock factor
    pfam06546
    Location:259443
    Vert_HS_TF; Vertebrate heat shock transcription factor
    pfam15035
    Location:110175
    Rootletin; Ciliary rootlet component, centrosome cohesion
  4. NM_001538.4NP_001529.2  heat shock factor protein 4 isoform a

    See identical proteins and their annotated locations for NP_001529.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter protein (isoform a). This variant, alternatively referred to as HSF4a, functions as an inhibitor of the constitutive expression of heat shock genes.
    Source sequence(s)
    AK307211, BX348481, CA412687, D87673
    Consensus CDS
    CCDS45510.1
    UniProtKB/Swiss-Prot
    Q9ULV5
    Conserved Domains (2) summary
    smart00415
    Location:16120
    HSF; heat shock factor
    pfam15035
    Location:110175
    Rootletin; Ciliary rootlet component, centrosome cohesion

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67163761..67169941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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