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HSF2 heat shock transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 3298, updated on 7-Jun-2020

Summary

Official Symbol
HSF2provided by HGNC
Official Full Name
heat shock transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:5225
See related
Ensembl:ENSG00000025156 MIM:140581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSF 2; HSTF 2
Summary
The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Expression
Broad expression in testis (RPKM 22.1), bone marrow (RPKM 8.8) and 23 other tissues See more
Orthologs

Genomic context

See HSF2 in Genome Data Viewer
Location:
6q22.31
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (122399551..122433119)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122720696..122754264)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377979 Neighboring gene uncharacterized LOC105377978 Neighboring gene RNA, U1 small nuclear 18, pseudogene Neighboring gene serine incorporator 1 Neighboring gene cAMP-dependent protein kinase inhibitor beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75048, MGC117376, MGC156196

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
heat shock factor protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029607.2 RefSeqGene

    Range
    5102..38569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135564.1NP_001129036.1  heat shock factor protein 2 isoform b

    See identical proteins and their annotated locations for NP_001129036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (b) missing an internal protein segment compared to isoform a. Updated summary and variant texts. [BR]
    Source sequence(s)
    AK225593, BC112323, BC121050, DA741774, Z99129
    Consensus CDS
    CCDS47470.1
    UniProtKB/Swiss-Prot
    Q03933
    Related
    ENSP00000400380.1, ENST00000452194.5
    Conserved Domains (2) summary
    smart00415
    Location:6110
    HSF; heat shock factor
    pfam06546
    Location:230494
    Vert_HS_TF; Vertebrate heat shock transcription factor
  2. NM_001243094.2NP_001230023.1  heat shock factor protein 2 isoform c

    See identical proteins and their annotated locations for NP_001230023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (c) with a distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC064622, DA741774
    UniProtKB/TrEMBL
    Q9BS48
    Conserved Domains (1) summary
    smart00415
    Location:6110
    HSF; heat shock factor
  3. NM_004506.4NP_004497.1  heat shock factor protein 2 isoform a

    See identical proteins and their annotated locations for NP_004497.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC112323, Z99129
    Consensus CDS
    CCDS5124.1
    UniProtKB/Swiss-Prot
    Q03933
    Related
    ENSP00000357440.4, ENST00000368455.9
    Conserved Domains (2) summary
    smart00415
    Location:6110
    HSF; heat shock factor
    pfam06546
    Location:230512
    Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    122399551..122433119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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