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Ubqn Ubiquilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32977, updated on 8-Apr-2026
Official Symbol
Ubqnprovided by FlyBase
Official Full Name
Ubiquilinprovided by FlyBase
Primary source
FLYBASE:FBgn0031057
Locus tag
Dmel_CG14224
See related
AllianceGenome:FB:FBgn0031057
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-18DEa; BEST:LD26923; CG14224; Chap; clone 5.42; Dmel\CG14224; dsk2; Dsk2; DSK2; dUbqln; dUbqn; UBQLN; UBQLN homolog; UBQLN1; ubqn
Summary
Enables proteasome binding activity. Involved in amyloid precursor protein metabolic process and ubiquitin-dependent protein catabolic process. Located in cytosol. Is expressed in several structures, including adult head; embryonic brain; embryonic/larval midgut; larval muscle system; and larval nervous system. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 15; frontotemporal dementia; and neurodegenerative disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and amyotrophic lateral sclerosis type 15. Orthologous to several human genes including UBQLN1 (ubiquilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See Ubqn in Genome Data Viewer
Location:
18E1-18E1; 1-64 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19683808..19687658)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19577841..19581691)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Zwischenferment Neighboring gene eye transformer Neighboring gene domeless Neighboring gene uncharacterized protein Neighboring gene Merlin

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Association of the Protein-Quality-Control Protein Ubiquilin-1 With Alzheimer's Disease Both in vitro and in vivo. Zhang C, et al. Front Neurosci, 2022. PMID 35401099, Free PMC Article
  2. The depletion of ubiquilin in Drosophila melanogaster disturbs neurochemical regulation to drive activity and behavioral deficits. Jantrapirom S, et al. Sci Rep, 2020 Mar 30. PMID 32231214, Free PMC Article
  3. Honeybee products and edible insect powders improve locomotive and learning abilities of Ubiquilin-knockdown Drosophila. Phokasem P, et al. BMC Complement Med Ther, 2020 Aug 31. PMID 32867756, Free PMC Article
  4. Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly. Jantrapirom S, et al. Biochim Biophys Acta Mol Basis Dis, 2018 Sep. PMID 29936333
  5. A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities. Jantrapirom S, et al. Exp Cell Res, 2018 Jan 15. PMID 29247619

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate a role for ubiquilins as regulators of autophagy by controlling mTOR serine-threonine kinases (mTOR)signalling.
    Title: Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
  2. Study demonstrated that the depletion of dUbqn markedly affected the expression and sub-cellular localization of Drosophila TDP-43 (TBPH), resulting in a cytoplasmic ubiquitin-positive TBPH pathology.
    Title: Depletion of Ubiquilin induces an augmentation in soluble ubiquitinated Drosophila TDP-43 to drive neurotoxicity in the fly.
  3. The genome of Drosophila contains a single UBQLN homolog (dUbqn) that shows high similarity to UBQLN1 and UBQLN2; therefore, the fly is a useful model for characterizing the role of UBQLN in vivo in neurological disorders affecting locomotion and learning abilities. We herein performed a phenotypic and molecular characterization of diverse dUbqn RNAi lines
    Title: A new Drosophila model of Ubiquilin knockdown shows the effect of impaired proteostasis on locomotive and learning abilities.
  4. Thus, the deubiquitinase Leon maintains ubiquitin homeostasis and proper Ubiquilin levels, preventing postsynaptic proteins from accumulation to confine postsynaptic growth.
    Title: USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin.
  5. overexpression of Dsk2 caused severe morphological abnormalities in the late pupal stages, leading to pharate adult lethality, accompanied by a huge accumulation of highly polyubiquitylated proteins.
    Title: Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit.
  6. Study shows that Drosophila Ubiquilin (Ubqn) binds to Drosophila Presenilin (Psn), and that loss of ubqn function suppresses phenotypes that arise from loss of psn function in vivo.
    Title: ubiquilin antagonizes presenilin and promotes neurodegeneration in Drosophila.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid precursor protein metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
ubiquilin
Names
CG14224-PA
CG14224-PB
Ubqn-PA
Ubqn-PB
ubiquilin 1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19683808..19687658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298528.1 → NP_001285457.1  ubiquilin, isoform B

    See identical proteins and their annotated locations for NP_001285457.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWD9
    Conserved Domains (4) summary
    smart00727
    Location:322 → 368
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:9 → 79
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:9 → 79
    UBQ; Ubiquitin homologues
    cd14399
    Location:501 → 537
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

  2. NM_134500.4 → NP_608344.1  ubiquilin, isoform A

    See identical proteins and their annotated locations for NP_608344.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWD9
    Related
    FBpp0074519
    Conserved Domains (4) summary
    smart00727
    Location:322 → 368
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:9 → 79
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:9 → 79
    UBQ; Ubiquitin homologues
    cd14399
    Location:501 → 537
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWD9 Q9VWD9

Gene LinkOut

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