U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Med12l mediator complex subunit 12-like [ Mus musculus (house mouse) ]

Gene ID: 329650, updated on 26-Sep-2022

Summary

Official Symbol
Med12lprovided by MGI
Official Full Name
mediator complex subunit 12-likeprovided by MGI
Primary source
MGI:MGI:2139916
See related
Ensembl:ENSMUSG00000056476 AllianceGenome:MGI:2139916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TRALPUSH; A130035F20; A630079M02
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of mediator complex. Orthologous to human MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 4.7), CNS E18 (RPKM 3.5) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Med12l in Genome Data Viewer
Location:
3; 3 D
Exon count:
48
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58912820..59225867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59005419..59318446)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene predicted gene, 25572 Neighboring gene G protein-coupled receptor 171 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 12-like protein
Names
mediator complex subunit 12-like protein
mediator of RNA polymerase II transcription, subunit 12 homolog-like
no opposite paired repeat protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177855.3NP_808523.2  mediator of RNA polymerase II transcription subunit 12-like protein

    Status: VALIDATED

    Source sequence(s)
    AA409741, AC122038, AK018323, AK037666, AK047743, BB646790, BP757618, BP757619, CA316095, CA318113, CB520516, CK638338
    Consensus CDS
    CCDS79912.1
    UniProtKB/Swiss-Prot
    Q8BQM9
    UniProtKB/TrEMBL
    A0A0G2JET8
    Related
    ENSMUSP00000142903.2, ENSMUST00000199659.5
    Conserved Domains (3) summary
    pfam09497
    Location:106161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18382062
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    58912820..59225867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252646.2XP_030108506.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18492073
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  2. XM_036163137.1XP_036019030.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18142040
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  3. XM_017319618.3XP_017175107.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X11

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18491931
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  4. XM_006501593.5XP_006501656.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18491931
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  5. XM_006501592.5XP_006501655.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18492068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  6. XM_006501589.5XP_006501652.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18492073
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  7. XM_006501591.5XP_006501654.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18492068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  8. XM_030252645.2XP_030108505.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18492073
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  9. XM_030252647.2XP_030108507.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2JET8
    Conserved Domains (3) summary
    pfam09497
    Location:106161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18382062
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  10. XM_006501587.5XP_006501650.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18442068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  11. XM_006501586.5XP_006501649.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18482072
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  12. XM_006501588.5XP_006501651.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18142040
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  13. XM_030252649.2XP_030108509.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

    Conserved Domains (3) summary
    pfam09497
    Location:106161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18032027
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283730
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  14. XM_030252648.1XP_030108508.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    Conserved Domains (3) summary
    pfam09497
    Location:106172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18142040
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RNA

  1. XR_004941335.1 RNA Sequence

  2. XR_004941334.1 RNA Sequence

  3. XR_003954333.2 RNA Sequence

  4. XR_375531.5 RNA Sequence