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Med12l mediator complex subunit 12-like [ Mus musculus (house mouse) ]

Gene ID: 329650, updated on 2-Oct-2018

Summary

Official Symbol
Med12lprovided by MGI
Official Full Name
mediator complex subunit 12-likeprovided by MGI
Primary source
MGI:MGI:2139916
See related
Ensembl:ENSMUSG00000056476 Vega:OTTMUSG00000052449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU044581; TRALPUSH; A130035F20; A630079M02
Expression
Broad expression in cerebellum adult (RPKM 4.7), CNS E18 (RPKM 3.5) and 23 other tissues See more
Orthologs

Genomic context

See Med12l in Genome Data Viewer
Location:
3; 3 D
Exon count:
46
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (59005594..59318416)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (58810900..59122338)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40060 Neighboring gene clarin 1 Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene G protein-coupled receptor 171 Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
beta-catenin binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 12-like protein
Names
mediator complex subunit 12-like protein
mediator of RNA polymerase II transcription, subunit 12 homolog-like
no opposite paired repeat protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177855.3NP_808523.2  mediator of RNA polymerase II transcription subunit 12-like protein

    Status: VALIDATED

    Source sequence(s)
    AA409741, AC122038, AK018323, AK037666, AK047743, BB646790, BP757618, BP757619, CA316095, CA318113, CB520516, CK638338
    Consensus CDS
    CCDS79912.1
    UniProtKB/Swiss-Prot
    Q8BQM9
    UniProtKB/TrEMBL
    A0A0G2JET8
    Related
    ENSMUSP00000142903.1, OTTMUSP00000070303, ENSMUST00000199659.4, OTTMUST00000131540
    Conserved Domains (3) summary
    pfam09497
    Location:103161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18392061
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283765
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    59005594..59318416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501588.3XP_006501651.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18152037
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294741
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  2. XM_006501585.3XP_006501648.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18502072
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  3. XM_006501589.3XP_006501652.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18502072
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  4. XM_006501591.3XP_006501654.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18502068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  5. XM_006501592.3XP_006501655.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18502068
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  6. XM_006501593.3XP_006501656.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

    Conserved Domains (2) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  7. XM_017319618.1XP_017175107.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

  8. XM_006501587.3XP_006501650.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18452067
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  9. XM_006501586.3XP_006501649.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

    Conserved Domains (3) summary
    pfam09497
    Location:103172
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18492071
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:294776
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
  10. XM_006501590.3XP_006501653.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

    Related
    ENSMUSP00000042269.7, ENSMUST00000040325.13
    Conserved Domains (3) summary
    pfam09497
    Location:103161
    Med12; Transcription mediator complex subunit Med12
    pfam12144
    Location:18042026
    Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
    pfam12145
    Location:283730
    Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

RNA

  1. XR_375531.3 RNA Sequence

  2. XR_001783698.1 RNA Sequence

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