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Pla2g4e phospholipase A2, group IVE [ Mus musculus (house mouse) ]

Gene ID: 329502, updated on 27-Nov-2024

Summary

Official Symbol
Pla2g4eprovided by MGI
Official Full Name
phospholipase A2, group IVEprovided by MGI
Primary source
MGI:MGI:1919144
See related
Ensembl:ENSMUSG00000050211 AllianceGenome:MGI:1919144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230096D22; Pla2epsilon; 2310026J01Rik
Summary
Enables several functions, including phosphatidylinositol phosphate binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipase A2 activity. Involved in N-acylphosphatidylethanolamine metabolic process and positive regulation of endocytic recycling. Located in early endosome membrane; lysosomal membrane; and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PLA2G4E (phospholipase A2 group IVE). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 3.5), cortex adult (RPKM 3.4) and 13 other tissues See more
Orthologs
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Genomic context

See Pla2g4e in Genome Data Viewer
Location:
2 E5; 2 60.24 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119996893..120075816, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120166412..120245630, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 28042 Neighboring gene phospholipase A2, group IVB (cytosolic) Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene EH-domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_05504 Neighboring gene STARR-positive B cell enhancer ABC_E226 Neighboring gene predicted gene, 52575 Neighboring gene STARR-seq mESC enhancer starr_05506 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVD Neighboring gene phospholipase A2, group IVF

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables N-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytosolic phospholipase A2 epsilon
Names
cPLA2-epsilon
calcium-dependent N-acyltransferase
phospholipase A2, group 4E
NP_001350019.1
NP_001350020.1
NP_001382399.1
NP_808513.2
XP_006499833.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363090.1NP_001350019.1  cytosolic phospholipase A2 epsilon isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL833774, AL844608, BX000525
    UniProtKB/TrEMBL
    B2RQF4
    Conserved Domains (2) summary
    cl11396
    Location:239781
    Patatin_and_cPLA2; Patatins and Phospholipases
    cl14603
    Location:1101
    C2; C2 domain
  2. NM_001363091.1NP_001350020.1  cytosolic phospholipase A2 epsilon isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL833774, AL844608, BC066085
    Conserved Domains (1) summary
    cl11396
    Location:6497
    Patatin_and_cPLA2; Patatins and Phospholipases
  3. NM_001395470.1NP_001382399.1  cytosolic phospholipase A2 epsilon isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL833774, AL844608, BX000525
    UniProtKB/TrEMBL
    B2RQF4
    Conserved Domains (3) summary
    cd07201
    Location:284826
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:38146
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:178285
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
  4. NM_177845.4NP_808513.2  cytosolic phospholipase A2 epsilon isoform 1

    See identical proteins and their annotated locations for NP_808513.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB195277, AL833774, AL844608
    Consensus CDS
    CCDS16616.1
    UniProtKB/Swiss-Prot
    Q50L42, Q8BX44
    UniProtKB/TrEMBL
    B2RQF4
    Related
    ENSMUSP00000087525.5, ENSMUST00000090071.5
    Conserved Domains (3) summary
    cd07201
    Location:328870
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:82190
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:324811
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    119996893..120075816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499770.5XP_006499833.2  cytosolic phospholipase A2 epsilon isoform X1

    UniProtKB/TrEMBL
    B2RQF4
    Conserved Domains (3) summary
    cd07201
    Location:261803
    cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
    cd04036
    Location:15123
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    pfam18695
    Location:155262
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain