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HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 3294, updated on 22-Sep-2022

Summary

Official Symbol
HSD17B2provided by HGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:5211
See related
Ensembl:ENSG00000086696 MIM:109685; AllianceGenome:HGNC:5211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD17; SDR9C2; EDH17B2
Summary
Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 177.2), placenta (RPKM 169.8) and 6 other tissues See more
Orthologs
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Genomic context

See HSD17B2 in Genome Data Viewer
Location:
16q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (82035253..82098534)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (88098974..88162234)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (82068858..82132139)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phospholipase C gamma 2 Neighboring gene RN7SK pseudogene 176 Neighboring gene uncharacterized LOC112268169 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene HSD17B2 antisense RNA 1 Neighboring gene MT-CYB pseudogene 28 Neighboring gene MT-ND6 pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in androgen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in placenta development IEA
Inferred from Electronic Annotation
more info
 
involved_in response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
17-beta-hydroxysteroid dehydrogenase type 2
Names
17-beta-HSD 2
20 alpha-hydroxysteroid dehydrogenase
20-alpha-HSD
E2DH
estradiol 17-beta-dehydrogenase 2
microsomal 17-beta-hydroxysteroid dehydrogenase
short chain dehydrogenase/reductase family 9C member 2
testosterone 17-beta-dehydrogenase
NP_002144.1
XP_047290005.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002153.3NP_002144.1  17-beta-hydroxysteroid dehydrogenase type 2

    See identical proteins and their annotated locations for NP_002144.1

    Status: VALIDATED

    Source sequence(s)
    AU139034, BC059170, BM670647, BP270993
    Consensus CDS
    CCDS10936.1
    UniProtKB/Swiss-Prot
    B2R7T4, P37059
    Related
    ENSP00000199936.4, ENST00000199936.9
    Conserved Domains (1) summary
    cd09805
    Location:83362
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    82035253..82098534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434049.1XP_047290005.1  17-beta-hydroxysteroid dehydrogenase type 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    88098974..88162234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)