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HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 [ Homo sapiens (human) ]

Gene ID: 3294, updated on 17-Jun-2019

Summary

Official Symbol
HSD17B2provided by HGNC
Official Full Name
hydroxysteroid 17-beta dehydrogenase 2provided by HGNC
Primary source
HGNC:HGNC:5211
See related
Ensembl:ENSG00000086696 MIM:109685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD17; SDR9C2; EDH17B2
Expression
Biased expression in duodenum (RPKM 177.2), placenta (RPKM 169.8) and 6 other tissues See more
Orthologs

Genomic context

See HSD17B2 in Genome Data Viewer
Location:
16q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (82035253..82098534)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (82068842..82132139)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene phospholipase C gamma 2 Neighboring gene RN7SK pseudogene 176 Neighboring gene uncharacterized LOC112268169 Neighboring gene short chain dehydrogenase/reductase family 42E, member 1 Neighboring gene uncharacterized LOC105371363 Neighboring gene MT-CYB pseudogene 28 Neighboring gene MT-ND6 pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Estrogen biosynthesis, organism-specific biosystem (from REACTOME)
    Estrogen biosynthesis, organism-specific biosystemIn female vertebrates, estrogens control reproductive system development and reproductive functions (Payne AH and Hales DB, 2004).
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Metabolism of steroid hormones, organism-specific biosystem (from REACTOME)
    Metabolism of steroid hormones, organism-specific biosystemSteroid hormones are synthesized primarily in the adrenal gland and gonads. They regulate energy metabolism and stress responses (glucocorticoids), salt balance (mineralocorticoids), and sexual devel...
  • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
    Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Ovarian steroidogenesis, conserved biosystem (from KEGG)
    Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Steroid Biosynthesis, organism-specific biosystem (from WikiPathways)
    Steroid Biosynthesis, organism-specific biosystem
    Steroid Biosynthesis
  • Steroid hormone biosynthesis, organism-specific biosystem (from KEGG)
    Steroid hormone biosynthesis, organism-specific biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...
  • Steroid hormone biosynthesis, conserved biosystem (from KEGG)
    Steroid hormone biosynthesis, conserved biosystemSteroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 co...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
estrogen biosynthetic process TAS
Traceable Author Statement
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
placenta development IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
estradiol 17-beta-dehydrogenase 2
Names
17-beta-HSD 2
17-beta-hydroxysteroid dehydrogenase type 2
20 alpha-hydroxysteroid dehydrogenase
20-alpha-HSD
E2DH
microsomal 17-beta-hydroxysteroid dehydrogenase
short chain dehydrogenase/reductase family 9C member 2
testosterone 17-beta-dehydrogenase
NP_002144.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002153.3NP_002144.1  estradiol 17-beta-dehydrogenase 2

    See identical proteins and their annotated locations for NP_002144.1

    Status: VALIDATED

    Source sequence(s)
    AU139034, BC059170, BM670647, BP270993
    Consensus CDS
    CCDS10936.1
    UniProtKB/Swiss-Prot
    P37059
    Related
    ENSP00000199936.4, ENST00000199936.9
    Conserved Domains (1) summary
    cd09805
    Location:83362
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    82035253..82098534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001751898.2 RNA Sequence

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