Rnf224 ring finger protein 224 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf224provided by MGI
Official Full Name: ring finger protein 224provided by MGI
Primary source: MGI:MGI:2685603
See related: Ensembl:ENSMUSG00000089953 AllianceGenome:MGI:2685603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm757
Summary: Predicted to enable metal ion binding activity. Orthologous to human RNF224 (ring finger protein 224). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 3.0), testis adult (RPKM 0.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 A3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25124488..25126799, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25234476..25236787, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Homology

Orthologs from Annotation Pipeline: 258 organisms have orthologs with human gene Rnf224
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RING finger protein 224

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033410.3 → NP_001028582.1 RING finger protein 224

See identical proteins and their annotated locations for NP_001028582.1

Status: VALIDATED

Source sequence(s)

AL732309

UniProtKB/Swiss-Prot

Q3UIW8

Related

ENSMUSP00000145470.2, ENSMUST00000091318.5

Conserved Domains (1) summary

cd00162
Location:22 → 73

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...