Treml2 triggering receptor expressed on myeloid cells-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Treml2provided by MGI
Official Full Name: triggering receptor expressed on myeloid cells-like 2provided by MGI
Primary source: MGI:MGI:2147038
See related: Ensembl:ENSMUSG00000071068 AllianceGenome:MGI:2147038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tlt2; Gm750
Summary: Predicted to enable signaling receptor activity. Predicted to be involved in T cell activation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in cell surface. Orthologous to human TREML2 (triggering receptor expressed on myeloid cells like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 15.4), thymus adult (RPKM 10.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 C

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48606419..48619562)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48299390..48312534)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TREM2 and TREML2 play opposite roles in microglia activation
Title: Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation.
Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells.
Title: Identification of TLT2 as an engulfment receptor for apoptotic cells.
TLT2 ligation enhances the neutrophil response to the formylated peptide FMLF, leading to increased reactive oxygen species production, degranulation, and chemotaxis
Title: TLT2 potentiates neutrophil antibacterial activity and chemotaxis in response to G protein-coupled receptor-mediated signaling.
(+) T-cell effector function, possibly by ligation of TLT-2 on tumour-infiltrating CD8(+) T cells at the local tumour site.
Title: Enhancement of effector CD8+ T-cell function by tumour-associated B7-H3 and modulation of its counter-receptor triggering receptor expressed on myeloid cell-like transcript 2 at tumour sites.
Data do not point to a role for TREML2 as a receptor for B7-H3.
Title: B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction.
analysis of an interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation
Title: Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.
TLT2 may be involved in the innate immune response based on its expression profile and the fact that it is up-regulated in response to inflammation.
Title: Trem-like transcript 2 is expressed on cells of the myeloid/granuloid and B lymphoid lineage and is up-regulated in response to inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Treml2 gene: The Treml2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 181 organisms have orthologs with human gene Treml2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in T cell activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trem-like transcript 2 protein

Names: TLT-2; triggering receptor expressed on myeloid cells-like 2a dominant; triggering receptor expressed on myeloid cells-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033405.2 → NP_001028577.2 trem-like transcript 2 protein isoform 1 precursor

See identical proteins and their annotated locations for NP_001028577.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC166164, AK037593, AK132018

Consensus CDS

CCDS37646.1

UniProtKB/Swiss-Prot

A6XA76, Q2LA85

Related

ENSMUSP00000156527.2, ENSMUST00000233092.2

Conserved Domains (1) summary

cl11960
Location:33 → 122

Ig; Immunoglobulin domain
NM_001360121.1 → NP_001347050.1 trem-like transcript 2 protein isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC166164, AC241601

Consensus CDS

CCDS89113.1

UniProtKB/TrEMBL

A0A3F2YNQ7

Related

ENSMUSP00000128215.3, ENSMUST00000170941.3

Conserved Domains (1) summary

cl11960
Location:33 → 122

Ig; Immunoglobulin domain