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Ubash3a ubiquitin associated and SH3 domain containing, A [ Mus musculus (house mouse) ]

Gene ID: 328795, updated on 2-Nov-2024

Summary

Official Symbol
Ubash3aprovided by MGI
Official Full Name
ubiquitin associated and SH3 domain containing, Aprovided by MGI
Primary source
MGI:MGI:1926074
See related
Ensembl:ENSMUSG00000042345 AllianceGenome:MGI:1926074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TULA; Sts-2; TULA-1; C330001M22; 5830413C03Rik
Summary
Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in cytosol and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 15.3), liver E14.5 (RPKM 3.3) and 4 other tissues See more
Orthologs
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Genomic context

See Ubash3a in Genome Data Viewer
Location:
17 A3.3- B1; 17 15.84 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31426842..31478655)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31207868..31259681)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15318 Neighboring gene trefoil factor 1 Neighboring gene transmembrane protease, serine 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31341993-31342102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31344766-31345042 Neighboring gene STARR-positive B cell enhancer ABC_E3196 Neighboring gene STARR-positive B cell enhancer ABC_E10945 Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene solute carrier family 37 (glycerol-3-phosphate transporter), member 1 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene phosphodiesterase 9A Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin-associated and SH3 domain-containing protein A
Names
T-cell ubiquitin ligand 1
suppressor of T-cell receptor signaling 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177823.4NP_808491.2  ubiquitin-associated and SH3 domain-containing protein A

    See identical proteins and their annotated locations for NP_808491.2

    Status: VALIDATED

    Source sequence(s)
    AK040572, BB736706, BC027561, BY227020
    Consensus CDS
    CCDS50054.1
    UniProtKB/Swiss-Prot
    Q3TED7, Q3V3E1
    Related
    ENSMUSP00000158544.2, ENSMUST00000236745.2
    Conserved Domains (4) summary
    cd07040
    Location:361456
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11937
    Location:241300
    SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
    cd14300
    Location:2561
    UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins
    pfam00300
    Location:413575
    His_Phos_1; Histidine phosphatase superfamily (branch 1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31426842..31478655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524434.5XP_006524497.1  ubiquitin-associated and SH3 domain-containing protein A isoform X1

    UniProtKB/TrEMBL
    A0A498WGR9
    Related
    ENSMUSP00000045890.9, ENSMUST00000048656.15
    Conserved Domains (3) summary
    cd07067
    Location:361476
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11937
    Location:241300
    SH3_UBASH3A; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein A
    cd14300
    Location:2561
    UBA_UBS3A_like; UBA domain found in ubiquitin-associated and SH3 domain-containing protein A (UBS3A) and similar proteins

RNA

  1. XR_003952136.2 RNA Sequence

  2. XR_876514.4 RNA Sequence

  3. XR_876515.4 RNA Sequence