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Lhfpl5 lipoma HMGIC fusion partner-like 5 [ Mus musculus (house mouse) ]

Gene ID: 328789, updated on 12-May-2024

Summary

Official Symbol
Lhfpl5provided by MGI
Official Full Name
lipoma HMGIC fusion partner-like 5provided by MGI
Primary source
MGI:MGI:1915382
See related
Ensembl:ENSMUSG00000062252 AllianceGenome:MGI:1915382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmhs; hscy; 9330179O15Rik
Summary
Acts upstream of or within auditory receptor cell stereocilium organization and detection of mechanical stimulus involved in sensory perception of sound. Located in apical plasma membrane and stereocilium tip. Is expressed in several structures, including cranial ganglion; genitourinary system; inner ear; lung; and superior cervical ganglion. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 67. Orthologous to human LHFPL5 (LHFPL tetraspan subfamily member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 2.7), cerebellum adult (RPKM 2.4) and 10 other tissues See more
Orthologs
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Genomic context

See Lhfpl5 in Genome Data Viewer
Location:
17 A3.3; 17 14.77 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28794330..28802567)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28575369..28583593)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene colipase-like 2 Neighboring gene STARR-seq mESC enhancer starr_42221 Neighboring gene microRNA 6969 Neighboring gene colipase, pancreatic Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1 Neighboring gene STARR-seq mESC enhancer starr_42228 Neighboring gene solute carrier family 26, member 8 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:28828272-28828381

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC117706

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium tip IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
LHFPL tetraspan subfamily member 5 protein
Names
lipoma HMGIC fusion partner-like 5 protein
tetraspan membrane protein of hair cell stereocilia
tetraspan transmembrane protein, hair cell stereocilia

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026571.2NP_080847.2  LHFPL tetraspan subfamily member 5 protein

    See identical proteins and their annotated locations for NP_080847.2

    Status: VALIDATED

    Source sequence(s)
    BC099483, BY721459
    Consensus CDS
    CCDS37530.1
    UniProtKB/Swiss-Prot
    B2KF30, Q4KL25
    Related
    ENSMUSP00000079598.7, ENSMUST00000080780.8
    Conserved Domains (1) summary
    pfam10242
    Location:25202
    L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28794330..28802567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524433.5XP_006524496.1  LHFPL tetraspan subfamily member 5 protein isoform X1

    See identical proteins and their annotated locations for XP_006524496.1

    UniProtKB/TrEMBL
    B2RWL4
    Conserved Domains (1) summary
    pfam10242
    Location:25202
    L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein