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Cyp18a1 Cytochrome P450 18a1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32858, updated on 9-Dec-2024

Summary

Official Symbol
Cyp18a1provided by FlyBase
Official Full Name
Cytochrome P450 18a1provided by FlyBase
Primary source
FLYBASE:FBgn0010383
Locus tag
Dmel_CG6816
See related
AllianceGenome:FB:FBgn0010383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
181H6T; 18a1; 26-hyd; CG6816; CT20826; cyp18; Cyp18; CYP18; cyp18a1; Cyp18A1; CYP18A1; CYP18A1-Dm; Cyt-P450-17C; CytP450; Dmel\CG6816; Eig17-1; ESTS:181H6T; P-450; P450
Summary
Enables steroid hydroxylase activity. Involved in chorion-containing eggshell formation and instar larval or pupal development. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including dorsal pharyngeal muscle cell; embryonic epipharynx; epithelium; gland; and gut section. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); extrapyramidal and movement disease; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Cyp18a1 in Genome Data Viewer
Location:
17D1-17D1; 1-60 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18688538..18693042, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18582571..18587075, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44707 Neighboring gene phantom Neighboring gene Cholecystokinin-like receptor at 17D1 Neighboring gene Cytochrome P450 308a1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in chorion-containing eggshell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ecdysteroid catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metamorphosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prepupal development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pupation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cytochrome P450 18a1
Names
CG6816-PA
CG6816-PB
Cyp18a1-PA
Cyp18a1-PB
cytochrome P450 17C
cytochrome P450-18a1
NP_523403.2
NP_728191.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18688538..18693042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078679.3NP_523403.2  cytochrome P450 18a1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523403.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5AC86, A5AC96, Q0KHQ8, Q27767, Q95078, Q9VWR4
    Related
    FBpp0074381
    Conserved Domains (1) summary
    pfam00067
    Location:54517
    p450; Cytochrome P450
  2. NM_167628.2NP_728191.1  cytochrome P450 18a1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5AC86, A5AC96, Q0KHQ8, Q27767, Q95078, Q9VWR4
    Related
    FBpp0074380
    Conserved Domains (1) summary
    pfam00067
    Location:54517
    p450; Cytochrome P450