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Npm2 nucleophosmin/nucleoplasmin 2 [ Mus musculus (house mouse) ]

Gene ID: 328440, updated on 6-Jun-2024

Summary

Official Symbol
Npm2provided by MGI
Official Full Name
nucleophosmin/nucleoplasmin 2provided by MGI
Primary source
MGI:MGI:1890811
See related
Ensembl:ENSMUSG00000047911 AllianceGenome:MGI:1890811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables chromatin binding activity. Acts upstream of or within chromatin remodeling. Located in nucleus. Is expressed in early conceptus and ovary. Orthologous to human NPM2 (nucleophosmin/nucleoplasmin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 2.6), ovary adult (RPKM 1.4) and 19 other tissues See more
Orthologs
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Genomic context

See Npm2 in Genome Data Viewer
Location:
14 D2; 14 36.42 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (70884736..70896694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (70647296..70661802, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene dematin actin binding protein Neighboring gene STARR-seq mESC enhancer starr_37085 Neighboring gene predicted gene, 38605 Neighboring gene fibroblast growth factor 17 Neighboring gene predicted gene, 52133 Neighboring gene exportin 7 Neighboring gene STARR-seq mESC enhancer starr_37090 Neighboring gene PCNA-associated factor pseudogene Neighboring gene docking protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC123506, MGC123507

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP-dependent protein-DNA complex displacement activity TAS
Traceable Author Statement
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blastocyst development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in single fertilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412003.1NP_001398932.1  nucleoplasmin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154563
    UniProtKB/Swiss-Prot
    Q80W85, Q8BW23
    UniProtKB/TrEMBL
    Q3SXW7
  2. NM_001412004.1NP_001398933.1  nucleoplasmin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154563
    UniProtKB/Swiss-Prot
    Q80W85, Q8BW23
    UniProtKB/TrEMBL
    Q3SXW7
  3. NM_001412005.1NP_001398934.1  nucleoplasmin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154563
    UniProtKB/Swiss-Prot
    Q80W85, Q8BW23
    UniProtKB/TrEMBL
    Q3SXW7
    Related
    ENSMUSP00000154427.2, ENSMUST00000228473.2
  4. NM_001425911.1NP_001412840.1  nucleoplasmin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154563
  5. NM_181345.4NP_851990.2  nucleoplasmin-2 isoform 1

    See identical proteins and their annotated locations for NP_851990.2

    Status: VALIDATED

    Source sequence(s)
    AC154563
    Consensus CDS
    CCDS27261.1
    UniProtKB/Swiss-Prot
    Q80W85, Q8BW23
    UniProtKB/TrEMBL
    Q3SXW7
    Related
    ENSMUSP00000057365.5, ENSMUST00000062629.5
    Conserved Domains (1) summary
    pfam03066
    Location:18116
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    70884736..70896694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)