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Mast4 microtubule associated serine/threonine kinase family member 4 [ Mus musculus (house mouse) ]

Gene ID: 328329, updated on 5-Jan-2023

Summary

Official Symbol
Mast4provided by MGI
Official Full Name
microtubule associated serine/threonine kinase family member 4provided by MGI
Primary source
MGI:MGI:1918885
See related
Ensembl:ENSMUSG00000034751 AllianceGenome:MGI:1918885
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0303; 4930420O11Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization; intracellular signal transduction; and peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytoplasm. Is expressed in brain; thymus primordium; and ventral grey horn. Orthologous to human MAST4 (microtubule associated serine/threonine kinase family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 6.5), bladder adult (RPKM 6.3) and 24 other tissues See more
Orthologs
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Genomic context

See Mast4 in Genome Data Viewer
Location:
13; 13 D1
Exon count:
38
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (102868996..103471607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (102732486..103335099, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41046 Neighboring gene RIKEN cDNA 1700099I09 gene Neighboring gene CD180 antigen Neighboring gene predicted gene 17160 Neighboring gene predicted gene, 30106 Neighboring gene predicted gene, 30050 Neighboring gene fibrillarin pseudogene Neighboring gene predicted gene 5454 Neighboring gene ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 4
NP_780380.2
XP_006517764.1
XP_006517765.1
XP_006517766.1
XP_006517767.1
XP_006517768.1
XP_006517769.1
XP_006517770.1
XP_011242974.1
XP_011242975.1
XP_011242976.1
XP_017171016.1
XP_017171017.1
XP_017171018.1
XP_017171019.1
XP_017171020.1
XP_017171021.1
XP_030103167.1
XP_030103168.1
XP_030103169.1
XP_030103170.1
XP_036013969.1
XP_036013970.1
XP_036013971.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175171.3NP_780380.2  microtubule-associated serine/threonine-protein kinase 4

    See identical proteins and their annotated locations for NP_780380.2

    Status: VALIDATED

    Source sequence(s)
    AC112791, AC114827, AC124387, AC165290, AC167975, AC239606
    Consensus CDS
    CCDS49349.1
    UniProtKB/Swiss-Prot
    Q811L6, Q8BME3
    Related
    ENSMUSP00000128464.2, ENSMUST00000167058.8
    Conserved Domains (4) summary
    smart00220
    Location:568841
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:11441222
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:567846
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:256529
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    102868996..103471607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315531.2XP_017171020.1  microtubule-associated serine/threonine-protein kinase 4 isoform X5

    Conserved Domains (3) summary
    cd00992
    Location:11471225
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:570849
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:256532
    DUF1908; Domain of unknown function (DUF1908)
  2. XM_017315530.2XP_017171019.1  microtubule-associated serine/threonine-protein kinase 4 isoform X4

    Conserved Domains (3) summary
    cd00992
    Location:11591237
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:582861
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:268544
    DUF1908; Domain of unknown function (DUF1908)
  3. XM_017315529.2XP_017171018.1  microtubule-associated serine/threonine-protein kinase 4 isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:11721250
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:595874
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:281557
    DUF1908; Domain of unknown function (DUF1908)
  4. XM_017315528.2XP_017171017.1  microtubule-associated serine/threonine-protein kinase 4 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:11811259
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:604883
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:293566
    DUF1908; Domain of unknown function (DUF1908)
  5. XM_017315532.2XP_017171021.1  microtubule-associated serine/threonine-protein kinase 4 isoform X6

    Conserved Domains (3) summary
    cd00992
    Location:11171195
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:607886
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:293569
    DUF1908; Domain of unknown function (DUF1908)
  6. XM_017315527.2XP_017171016.1  microtubule-associated serine/threonine-protein kinase 4 isoform X1

    Conserved Domains (3) summary
    cd00992
    Location:11841262
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:607886
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:293569
    DUF1908; Domain of unknown function (DUF1908)
  7. XM_036158077.1XP_036013970.1  microtubule-associated serine/threonine-protein kinase 4 isoform X22

    Conserved Domains (3) summary
    cd00992
    Location:878956
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57330
    DUF1908; Domain of unknown function (DUF1908)
  8. XM_006517705.5XP_006517768.1  microtubule-associated serine/threonine-protein kinase 4 isoform X17

    Conserved Domains (3) summary
    cd00992
    Location:9451023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:368647
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57330
    DUF1908; Domain of unknown function (DUF1908)
  9. XM_006517704.5XP_006517767.1  microtubule-associated serine/threonine-protein kinase 4 isoform X16

    Conserved Domains (3) summary
    cd00992
    Location:9481026
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:371650
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:57333
    DUF1908; Domain of unknown function (DUF1908)
  10. XM_030247309.2XP_030103169.1  microtubule-associated serine/threonine-protein kinase 4 isoform X13

    UniProtKB/TrEMBL
    A0A0A6YXG1
    Related
    ENSMUSP00000141977.3, ENSMUST00000194446.7
    Conserved Domains (3) summary
    cd00992
    Location:9571035
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:380659
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:69342
    DUF1908; Domain of unknown function (DUF1908)
  11. XM_006517702.5XP_006517765.1  microtubule-associated serine/threonine-protein kinase 4 isoform X12

    Conserved Domains (3) summary
    cd00992
    Location:9601038
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:383662
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:69345
    DUF1908; Domain of unknown function (DUF1908)
  12. XM_030247307.2XP_030103167.1  microtubule-associated serine/threonine-protein kinase 4 isoform X9

    UniProtKB/TrEMBL
    A0A668KMA1
    Related
    ENSMUSP00000159269.2, ENSMUST00000239261.2
    Conserved Domains (3) summary
    cd00992
    Location:9701048
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:393672
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:82355
    DUF1908; Domain of unknown function (DUF1908)
  13. XM_036158076.1XP_036013969.1  microtubule-associated serine/threonine-protein kinase 4 isoform X8

    Conserved Domains (3) summary
    cd00992
    Location:9731051
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:396675
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:82358
    DUF1908; Domain of unknown function (DUF1908)
  14. XM_006517701.5XP_006517764.1  microtubule-associated serine/threonine-protein kinase 4 isoform X7

    Conserved Domains (3) summary
    cd00992
    Location:9851063
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:408687
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:94370
    DUF1908; Domain of unknown function (DUF1908)
  15. XM_006517706.4XP_006517769.1  microtubule-associated serine/threonine-protein kinase 4 isoform X18

    Conserved Domains (3) summary
    cd00992
    Location:9401018
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:363642
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:49325
    DUF1908; Domain of unknown function (DUF1908)
  16. XM_030247308.2XP_030103168.1  microtubule-associated serine/threonine-protein kinase 4 isoform X11

    Conserved Domains (3) summary
    cd00992
    Location:9641042
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:387666
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:76349
    DUF1908; Domain of unknown function (DUF1908)
  17. XM_011244672.3XP_011242974.1  microtubule-associated serine/threonine-protein kinase 4 isoform X10

    UniProtKB/TrEMBL
    E9QPR4
    Related
    ENSMUSP00000096808.4, ENSMUST00000099202.10
    Conserved Domains (3) summary
    cd00992
    Location:9671045
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:390669
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:76352
    DUF1908; Domain of unknown function (DUF1908)
  18. XM_030247310.2XP_030103170.1  microtubule-associated serine/threonine-protein kinase 4 isoform X19

    Conserved Domains (3) summary
    cd00992
    Location:9371015
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:360639
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:49322
    DUF1908; Domain of unknown function (DUF1908)
  19. XM_011244673.4XP_011242975.1  microtubule-associated serine/threonine-protein kinase 4 isoform X15

    UniProtKB/TrEMBL
    E9PWX8
    Related
    ENSMUSP00000131651.2, ENSMUST00000171791.8
    Conserved Domains (3) summary
    cd00992
    Location:9521030
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64337
    DUF1908; Domain of unknown function (DUF1908)
  20. XM_006517703.5XP_006517766.1  microtubule-associated serine/threonine-protein kinase 4 isoform X14

    Conserved Domains (3) summary
    cd00992
    Location:9551033
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:378657
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64340
    DUF1908; Domain of unknown function (DUF1908)
  21. XM_011244674.4XP_011242976.1  microtubule-associated serine/threonine-protein kinase 4 isoform X21

    Conserved Domains (3) summary
    cd00992
    Location:885963
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:64337
    DUF1908; Domain of unknown function (DUF1908)
  22. XM_036158078.1XP_036013971.1  microtubule-associated serine/threonine-protein kinase 4 isoform X23

    Conserved Domains (3) summary
    cd00992
    Location:798876
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:221500
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:1183
    DUF1908; Domain of unknown function (DUF1908)
  23. XM_006517707.4XP_006517770.1  microtubule-associated serine/threonine-protein kinase 4 isoform X20

    Conserved Domains (3) summary
    cd00992
    Location:9371015
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:360639
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:46322
    DUF1908; Domain of unknown function (DUF1908)