Slc39a9 solute carrier family 39 (zinc transporter), member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc39a9provided by MGI
Official Full Name: solute carrier family 39 (zinc transporter), member 9provided by MGI
Primary source: MGI:MGI:1914820
See related: Ensembl:ENSMUSG00000048833 AllianceGenome:MGI:1914820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Zip9; 2010002A02Rik; 2610511I23Rik; 4833420E20Rik
Summary: Predicted to enable G protein-coupled receptor activity; androgen binding activity; and zinc efflux transmembrane transporter activity. Involved in regulation of cellular response to testosterone stimulus. Predicted to be located in several cellular components, including mitochondrial membrane; perinuclear region of cytoplasm; and trans-Golgi network. Orthologous to human SLC39A9 (solute carrier family 39 member 9). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Ubiquitous expression in large intestine adult (RPKM 22.7), colon adult (RPKM 21.1) and 28 other tissues See more
Orthologs: all
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Genomic context

Location:: 12 C3; 12 36.91 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (80690657..80730116)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (80643883..80683342)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.
Title: ZIP9 mediates the effects of DHT on learning, memory and hippocampal synaptic plasticity of male Tfm and APP/PS1 mice.
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
Title: Non-classical testosterone signaling in spermatogenic GC-2 cells is mediated through ZIP9 interacting with Gnα11.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc39a9 (e-PCR), detects polymorphism
- UniSTS:547109

RH128956 (e-PCR)
- UniSTS:212264

AW209151 (e-PCR)
- UniSTS:180417

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables androgen binding	IEA Inferred from Electronic Annotation more info
enables androgen binding	ISO Inferred from Sequence Orthology more info
enables androgen binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc efflux transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular zinc ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to testosterone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc transporter ZIP9

Names: ZIP-9; solute carrier family 39 member 9; zrt- and Irt-like protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026244.2 → NP_080520.2 zinc transporter ZIP9

See identical proteins and their annotated locations for NP_080520.2

Status: VALIDATED

Source sequence(s)

BC058649, BC072655, BY148507, CO040789

Consensus CDS

CCDS49099.1

UniProtKB/Swiss-Prot

B2RY14, Q8BFU1

UniProtKB/TrEMBL

A0A1W2P6Y1

Related

ENSMUSP00000082343.6, ENSMUST00000085245.7

Conserved Domains (1) summary

pfam02535
Location:9 → 302

Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

80690657..80730116

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516033.4 → XP_006516096.1 zinc transporter ZIP9 isoform X3

Conserved Domains (1) summary

cl00437
Location:9 → 144

Zip; ZIP Zinc transporter
XM_017315121.3 → XP_017170610.1 zinc transporter ZIP9 isoform X1

UniProtKB/Swiss-Prot

B2RY14, Q8BFU1

UniProtKB/TrEMBL

A0A1W2P6Y1

Conserved Domains (1) summary

pfam02535
Location:9 → 302

Zip; ZIP Zinc transporter
XM_006516032.4 → XP_006516095.1 zinc transporter ZIP9 isoform X2

Conserved Domains (1) summary

cl00437
Location:56 → 226

Zip; ZIP Zinc transporter
XM_006516034.5 → XP_006516097.1 zinc transporter ZIP9 isoform X4

Conserved Domains (1) summary

pfam02535
Location:9 → 278

Zip; ZIP Zinc transporter