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Slc7a15 solute carrier family 7 (cationic amino acid transporter, y+ system), member 15 [ Mus musculus (house mouse) ]

Gene ID: 328059, updated on 9-Mar-2023

Summary

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Official Symbol
Slc7a15provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 15provided by MGI
Primary source
MGI:MGI:3045351
See related
Ensembl:ENSMUSG00000020600 AllianceGenome:MGI:3045351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arpat
Summary
Enables amino acid transmembrane transporter activity. Acts upstream of or within amino acid transport. Part of protein-containing complex. Orthologous to human SLC7A15P (solute carrier family 7 member 15, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 25.2), duodenum adult (RPKM 22.5) and 3 other tissues See more
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Genomic context

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See Slc7a15 in Genome Data Viewer
Location:
12; 12 A1.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (8578481..8649066, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (8528481..8599066, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5033421B08 gene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ras homolog family member B Neighboring gene pumilio RNA-binding family member 2 Neighboring gene predicted gene 4755

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution. Fernández E, et al. J Biol Chem, 2005 May 13. PMID 15757906
  2. Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. Yu Y, et al. Nat Commun, 2022 Mar 3. PMID 35241668, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. characterization of arpAT (affinity aromatic-preferring amino acid transporter)
    Title: Identification and functional characterization of a novel low affinity aromatic-preferring amino acid transporter (arpAT). One of the few proteins silenced during primate evolution.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 2010001P20Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aromatic-preferring amino acid transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038660.2 → NP_001033749.1  aromatic-preferring amino acid transporter isoform 1

    See identical proteins and their annotated locations for NP_001033749.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC117236, AC166361, AK008024, AK033481
    Consensus CDS
    CCDS25800.1
    UniProtKB/TrEMBL
    Q50E62, Q8BZV2, Q9D8H4
    Related
    ENSMUSP00000093548.4, ENSMUST00000095863.10
    Conserved Domains (1) summary
    TIGR00911
    Location:5 → 481
    2A0308; L-type amino acid transporter

  2. NM_001286385.1 → NP_001273314.1  aromatic-preferring amino acid transporter isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC117236, AK008024
    UniProtKB/TrEMBL
    Q9D8H4
    Related
    ENSMUST00000129465.2
    Conserved Domains (1) summary
    TIGR00911
    Location:5 → 252
    2A0308; L-type amino acid transporter

  3. NM_177802.3 → NP_808470.1  aromatic-preferring amino acid transporter isoform 2

    See identical proteins and their annotated locations for NP_808470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks part of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC117236, AC166361, AK033481
    Consensus CDS
    CCDS25801.1
    UniProtKB/TrEMBL
    Q8BZV2
    Related
    ENSMUSP00000047873.3, ENSMUST00000036938.9
    Conserved Domains (1) summary
    TIGR00911
    Location:2 → 221
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    8578481..8649066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243876.3 → XP_011242178.1  aromatic-preferring amino acid transporter isoform X1

    Conserved Domains (1) summary
    TIGR00911
    Location:5 → 453
    2A0308; L-type amino acid transporter

  2. XM_006515119.4 → XP_006515182.1  aromatic-preferring amino acid transporter isoform X4

    See identical proteins and their annotated locations for XP_006515182.1

    UniProtKB/TrEMBL
    Q8BZV2
    Related
    ENSMUSP00000129806.2, ENSMUST00000165657.3
    Conserved Domains (1) summary
    TIGR00911
    Location:2 → 221
    2A0308; L-type amino acid transporter

  3. XM_006515118.5 → XP_006515181.1  aromatic-preferring amino acid transporter isoform X3

    Conserved Domains (1) summary
    TIGR00911
    Location:5 → 252
    2A0308; L-type amino acid transporter

  4. XM_011243877.3 → XP_011242179.1  aromatic-preferring amino acid transporter isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:5 → 382
    2A0308; L-type amino acid transporter
Nucleotide Protein Strain
Heading Accession and Version

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