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Med13 mediator complex subunit 13 [ Mus musculus (house mouse) ]

Gene ID: 327987, updated on 18-Jun-2024

Summary

Official Symbol
Med13provided by MGI
Official Full Name
mediator complex subunit 13provided by MGI
Primary source
MGI:MGI:3029632
See related
Ensembl:ENSMUSG00000034297 AllianceGenome:MGI:3029632
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thrap1; Trap240; D030023K18; 1110067M05Rik
Summary
Predicted to enable thyroid hormone receptor binding activity and transcription coactivator activity. Involved in cholesterol homeostasis; negative regulation of DNA-binding transcription factor activity; and triglyceride homeostasis. Part of mediator complex. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 6.7), whole brain E14.5 (RPKM 6.6) and 28 other tissues See more
Orthologs
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Genomic context

See Med13 in Genome Data Viewer
Location:
11 C; 11 51.75 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (86157859..86248422, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (86267033..86357596, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene BRCA1 interacting protein C-terminal helicase 1 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E1425 Neighboring gene BRCA1 interacting protein C-terminal helicase 1, opposite strand Neighboring gene integrator complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_30265 Neighboring gene predicted gene, 57586 Neighboring gene STARR-positive B cell enhancer ABC_E10702 Neighboring gene STARR-positive B cell enhancer ABC_E1837 Neighboring gene STARR-positive B cell enhancer ABC_E9142 Neighboring gene predicted gene, 38937 Neighboring gene predicted gene, 33528

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nuclear thyroid hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CKM complex ISO
Inferred from Sequence Orthology
more info
 
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 13
Names
Zmediator complex subunit 13
mediator of RNA polymerase II transcription, subunit 13
thyroid hormone receptor associated protein 1
thyroid hormone receptor associated protein, 240 kDa subunit
thyroid hormone receptor-associated protein complex 240 kDa component

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080931.2NP_001074400.1  mediator of RNA polymerase II transcription subunit 13

    See identical proteins and their annotated locations for NP_001074400.1

    Status: VALIDATED

    Source sequence(s)
    AL592065, AL596256
    Consensus CDS
    CCDS36267.1
    UniProtKB/Swiss-Prot
    Q3V3P6, Q5SWW4, Q6ZQ90
    Related
    ENSMUSP00000044268.9, ENSMUST00000043624.9
    Conserved Domains (2) summary
    pfam06333
    Location:16372158
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:14384
    Med13_N; Mediator complex subunit 13 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    86157859..86248422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)