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Dnah2 dynein, axonemal, heavy chain 2 [ Mus musculus (house mouse) ]

Gene ID: 327954, updated on 10-Oct-2019

Summary

Official Symbol
Dnah2provided by MGI
Official Full Name
dynein, axonemal, heavy chain 2provided by MGI
Primary source
MGI:MGI:107731
See related
Ensembl:ENSMUSG00000005237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnhd3; Dnahc2; 4930564A01; D130094J20; 2900022L05Rik; D330014H01Rik
Expression
Biased expression in testis adult (RPKM 9.8), ovary adult (RPKM 1.9) and 5 other tissues See more
Orthologs

Genomic context

See Dnah2 in Genome Data Viewer
Location:
11 B3; 11 42.63 cM
Exon count:
95
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69420807..69549108, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69234311..69362610, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 88 Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene KDM1 lysine (K)-specific demethylase 6B Neighboring gene predicted gene, 51903 Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to Trp53 Neighboring gene ribosomal protein S27, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, minus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
motor activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner dynein arm ISM
Inferred from Sequence Model
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motile cilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein heavy chain 2, axonemal
Names
axonemal beta dynein heavy chain 2
axonemal dynein heavy chain
ciliary dynein heavy chain 2
dynein heavy chain domain 3
dynein, axon, heavy chain 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081330.1NP_001074799.1  dynein heavy chain 2, axonemal

    Status: VALIDATED

    Source sequence(s)
    AL596125, AL731687
    Consensus CDS
    CCDS36192.1
    UniProtKB/TrEMBL
    D3Z667
    Related
    ENSMUSP00000104299.1, ENSMUST00000108659.1
    Conserved Domains (6) summary
    pfam03028
    Location:37594450
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:275760
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12581663
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30413373
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34013617
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18002030
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    69420807..69549108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249074.3XP_011247376.1  dynein heavy chain 2, axonemal isoform X1

    Conserved Domains (6) summary
    pfam03028
    Location:38414532
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:275842
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13401745
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31233455
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34833699
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18822112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_006533552.4XP_006533615.1  dynein heavy chain 2, axonemal isoform X2

    Conserved Domains (6) summary
    pfam03028
    Location:38054496
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:239806
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13041709
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30873419
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34473663
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18462076
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_030246089.1XP_030101949.1  dynein heavy chain 2, axonemal isoform X4

  4. XM_011249077.3XP_011247379.1  dynein heavy chain 2, axonemal isoform X5

    Conserved Domains (6) summary
    pfam03028
    Location:37424433
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:275842
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13401745
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30243356
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33843600
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18822112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_006533554.4XP_006533617.1  dynein heavy chain 2, axonemal isoform X6

    Conserved Domains (6) summary
    pfam03028
    Location:37334424
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:167734
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12321637
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30153347
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33753591
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:17742004
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011249075.2XP_011247377.1  dynein heavy chain 2, axonemal isoform X3

    Conserved Domains (6) summary
    pfam03028
    Location:37594450
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:193760
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12581663
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:30413373
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34013617
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18002030
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_030246090.1XP_030101950.1  dynein heavy chain 2, axonemal isoform X8

  8. XM_006533559.3XP_006533622.1  dynein heavy chain 2, axonemal isoform X10

    See identical proteins and their annotated locations for XP_006533622.1

    Conserved Domains (6) summary
    pfam03028
    Location:30663757
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:167
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:565970
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:23482680
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:27082924
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:11071337
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_006533560.4XP_006533623.1  dynein heavy chain 2, axonemal isoform X10

    See identical proteins and their annotated locations for XP_006533623.1

    Conserved Domains (6) summary
    pfam03028
    Location:30663757
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:167
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:565970
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:23482680
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:27082924
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:11071337
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. XM_017314611.2XP_017170100.1  dynein heavy chain 2, axonemal isoform X10

    Conserved Domains (6) summary
    pfam03028
    Location:30663757
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:167
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:565970
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:23482680
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:27082924
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:11071337
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  11. XM_030246092.1XP_030101952.1  dynein heavy chain 2, axonemal isoform X11

  12. XM_011249079.3XP_011247381.1  dynein heavy chain 2, axonemal isoform X7

    Conserved Domains (6) summary
    pfam03028
    Location:38414068
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:275842
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13401745
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31233455
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34833699
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18822112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  13. XM_011249081.3XP_011247383.1  dynein heavy chain 2, axonemal isoform X9

    Conserved Domains (5) summary
    pfam08385
    Location:275842
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13401745
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31233455
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34833699
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:18822112
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. XR_003949463.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177617.2: Suppressed sequence

    Description
    NM_177617.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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