HDGF heparin binding growth factor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: HDGFprovided by VGNC
Official Full Name: heparin binding growth factorprovided by VGNC
Primary source: VGNC:VGNC:29787
See related: BGD:BT22463; EnsemblRapid:ENSBTAG00070012048
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (14082647..14091949)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HDGF is synthesized similarly by the endometrium and embryo, and it may exert embryotropic effects by autocrine and/or paracrine mechanisms.
Title: Hepatoma-derived growth factor: from the bovine uterus to the in vitro embryo culture.
involvement of HDGF during the initiation phase of the apoptotic process downstream from an initiator Caspase and regulation of this protein by phosphorylation in the nucleus
Title: HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase-dependent way.

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General gene information

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General protein information

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Preferred Names: hepatoma-derived growth factor

Names: hepatoma derived growth factor; hepatoma-derived growth factor (high-mobility group protein 1-like)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175832.2 → NP_787026.1 hepatoma-derived growth factor

See identical proteins and their annotated locations for NP_787026.1

Status: PROVISIONAL

Source sequence(s)

AJ237996

UniProtKB/Swiss-Prot

Q9XSK7

UniProtKB/TrEMBL

Q08E18

Related

ENSBTAP00070016289.1, ENSBTAT00070027273.1

Conserved Domains (1) summary

cd05834
Location:8 → 92

HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...