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CG6867 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32782, updated on 5-Jul-2025
Official Symbol
CG6867provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030887
Locus tag
Dmel_CG6867
See related
AllianceGenome:FB:FBgn0030887
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CT21241; Dmel\CG6867
Summary
Involved in motor neuron axon guidance and synaptic target inhibition. Predicted to be active in extracellular space. Is expressed in muscle cell of A1-7 ventral longitudinal muscle 2 and muscle cell of ventral longitudinal muscle 1. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin) and OLFML2B (olfactomedin like 2B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See CG6867 in Genome Data Viewer
Location:
16F5-16F5; 1-59 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18023870..18028261)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17917903..17922294)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Shaker Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 16F

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Wnt4 is a local repulsive cue that determines synaptic target specificity. Inaki M, et al. Curr Biol, 2007 Sep 18. PMID 17764943
  2. Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma. Carbone MA, et al. PLoS One, 2009. PMID 19148291, Free PMC Article
  3. Generation of neuromuscular specificity in Drosophila: novel mechanisms revealed by new technologies. Nose A. Front Mol Neurosci, 2012. PMID 22586369, Free PMC Article
  4. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain. Mukherjee C, et al. Cell Metab, 2020 Aug 4. PMID 32531201, Free PMC Article
  5. Comparative analysis of Hox downstream genes in Drosophila. Hueber SD, et al. Development, 2007 Jan. PMID 17166915

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic target inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
uncharacterized protein
Names
CG6867-PA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18023870..18028261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133034.6 → NP_573262.2  uncharacterized protein Dmel_CG6867

    See identical proteins and their annotated locations for NP_573262.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGN3, Q9VWZ7
    Related
    FBpp0088539
    Conserved Domains (5) summary
    cd00096
    Location:546 → 612
    Ig; Immunoglobulin domain
    pfam01391
    Location:306 → 364
    Collagen; Collagen triple helix repeat (20 copies)
    smart00408
    Location:449 → 511
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:442 → 525
    IG_like; Immunoglobulin like
    pfam02191
    Location:694 → 937
    OLF; Olfactomedin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGN3 Q8IGN3
Q9VWZ7 Q9VWZ7

Gene LinkOut

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