Format

Send to:

Choose Destination

SERPINA9 serpin family A member 9 [ Homo sapiens (human) ]

Gene ID: 327657, updated on 24-Nov-2020

Summary

Official Symbol
SERPINA9provided by HGNC
Official Full Name
serpin family A member 9provided by HGNC
Primary source
HGNC:HGNC:15995
See related
Ensembl:ENSG00000170054 MIM:615677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCET1; SERPINA11; SERPINA11b
Expression
Biased expression in lymph node (RPKM 11.5) and appendix (RPKM 4.1) See more
Orthologs

Genomic context

See SERPINA9 in Genome Data Viewer
Location:
14q32.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94462721..94476227, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94929058..94942670, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene serpin family A member 11 Neighboring gene uncharacterized LOC105370635 Neighboring gene serpin family A member 12 Neighboring gene serpin family A member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131906

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serpin A9
Names
centerin
germinal center B-cell-expressed transcript 1 protein
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
serine proteinase inhibitor A11
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042518.2NP_001035983.2  serpin A9 isoform B precursor

    Status: VALIDATED

    Source sequence(s)
    AL132708
    Consensus CDS
    CCDS41983.1
    Related
    ENSP00000298845.7, ENST00000298845.11
  2. NM_001284275.2NP_001271204.2  serpin A9 isoform C

    Status: VALIDATED

    Source sequence(s)
    AL132708
    Related
    ENSP00000414092.2, ENST00000448305.6
  3. NM_001284276.2NP_001271205.1  serpin A9 isoform D

    Status: VALIDATED

    Source sequence(s)
    AL132708
    Consensus CDS
    CCDS61542.1
    UniProtKB/Swiss-Prot
    Q86WD7
    Related
    ENSP00000409012.2, ENST00000424550.6
    Conserved Domains (1) summary
    cl00137
    Location:1280
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  4. NM_175739.4NP_783866.3  serpin A9 isoform A precursor

    Status: VALIDATED

    Source sequence(s)
    AL132708
    Consensus CDS
    CCDS41982.1
    Related
    ENSP00000501517.1, ENST00000674397.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94462721..94476227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536716.2XP_011535018.1  serpin A9 isoform X2

    See identical proteins and their annotated locations for XP_011535018.1

    UniProtKB/Swiss-Prot
    Q86WD7
    Conserved Domains (1) summary
    cl00137
    Location:1331
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
  2. XM_011536714.2XP_011535016.1  serpin A9 isoform X1

    See identical proteins and their annotated locations for XP_011535016.1

    UniProtKB/Swiss-Prot
    Q86WD7
    Related
    ENSP00000369723.3, ENST00000380365.7
    Conserved Domains (1) summary
    cd02056
    Location:48411
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  3. XM_011536715.2XP_011535017.1  serpin A9 isoform X1

    See identical proteins and their annotated locations for XP_011535017.1

    UniProtKB/Swiss-Prot
    Q86WD7
    Conserved Domains (1) summary
    cd02056
    Location:48411
    alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...
  4. XM_011536717.1XP_011535019.1  serpin A9 isoform X2

    See identical proteins and their annotated locations for XP_011535019.1

    UniProtKB/Swiss-Prot
    Q86WD7
    Conserved Domains (1) summary
    cl00137
    Location:1331
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Support Center