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HRH2 histamine receptor H2 [ Homo sapiens (human) ]

Gene ID: 3274, updated on 3-Jun-2018
Official Symbol
HRH2provided by HGNC
Official Full Name
histamine receptor H2provided by HGNC
Primary source
HGNC:HGNC:5183
See related
Ensembl:ENSG00000113749 MIM:142703; Vega:OTTHUMG00000130660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2R
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues See more
Orthologs
See HRH2 in Genome Data Viewer
Location:
5q35.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (175657762..175710756)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175084847..175136239)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene sideroflexin 1 Neighboring gene RNA, 7SK small nuclear pseudogene 148 Neighboring gene uncharacterized LOC105377743 Neighboring gene RNA, U6 small nuclear 226, pseudogene Neighboring gene uncharacterized LOC105377744 Neighboring gene complexin 2 Neighboring gene uncharacterized LOC107986485

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Histamine receptors, organism-specific biosystem (from REACTOME)
    Histamine receptors, organism-specific biosystemHistamine is a biogenic amine involved in local immune responses, regulation of gut function and neurotransmission. It exerts its actions by binding to histamine receptors. There are four receptors i...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Secretion of Hydrochloric Acid in Parietal Cells, organism-specific biosystem (from WikiPathways)
    Secretion of Hydrochloric Acid in Parietal Cells, organism-specific biosystemGastric parietal cells are stomach epithelial cells. They secrete gastric acid and intrinsic factor. This pathway is primarily based on https://en.wikipedia.org/wiki/Parietal_cell
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histamine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
Traceable Author Statement
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
epithelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gastrin-induced gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
gland development IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
memory IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
histamine H2 receptor
Names
HH2R
gastric receptor 1
gastric receptor I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131055.1NP_001124527.1  histamine H2 receptor

    See identical proteins and their annotated locations for NP_001124527.1

    Status: REVIEWED

    Source sequence(s)
    BC054510, CF147823
    Consensus CDS
    CCDS47344.1
    UniProtKB/Swiss-Prot
    P25021
    Related
    ENSP00000366506.2, OTTHUMP00000161242, ENST00000377291.2, OTTHUMT00000253150
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    175657762..175710756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714865.3XP_006714928.1  histamine H2 receptor isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:35288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_005265904.3XP_005265961.1  histamine H2 receptor isoform X1

    See identical proteins and their annotated locations for XP_005265961.1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Related
    ENSP00000489742.1, OTTHUMP00000282329, ENST00000636584.1, OTTHUMT00000489850
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_006714864.4XP_006714927.1  histamine H2 receptor isoform X1

    See identical proteins and their annotated locations for XP_006714927.1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011534548.3XP_011532850.1  histamine H2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011532850.1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_011534549.3XP_011532851.1  histamine H2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011532851.1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_017009426.2XP_016864915.1  histamine H2 receptor isoform X1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. XR_245274.3 RNA Sequence

    Related
    ENST00000624694.2, OTTHUMT00000489849

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022304.2: Suppressed sequence

    Description
    NM_022304.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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