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HRH2 histamine receptor H2 [ Homo sapiens (human) ]

Gene ID: 3274, updated on 28-Nov-2021

Summary

Official Symbol
HRH2provided by HGNC
Official Full Name
histamine receptor H2provided by HGNC
Primary source
HGNC:HGNC:5183
See related
Ensembl:ENSG00000113749 MIM:142703
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2R; HH2R
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Broad expression in bone marrow (RPKM 7.6), heart (RPKM 5.0) and 18 other tissues See more
Orthologs
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Genomic context

See HRH2 in Genome Data Viewer
Location:
5q35.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (175657762..175710756)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175085074..175137759)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene sideroflexin 1 Neighboring gene RN7SK pseudogene 148 Neighboring gene uncharacterized LOC105377743 Neighboring gene Sharpr-MPRA regulatory region 12912 Neighboring gene RNA, U6 small nuclear 226, pseudogene Neighboring gene uncharacterized LOC105377744 Neighboring gene complexin 2 Neighboring gene uncharacterized LOC107986485

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histamine H2 receptor
Names
gastric receptor 1
gastric receptor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131055.2NP_001124527.1  histamine H2 receptor isoform 1

    See identical proteins and their annotated locations for NP_001124527.1

    Status: REVIEWED

    Source sequence(s)
    BC054510, CF147823
    Consensus CDS
    CCDS47344.1
    UniProtKB/Swiss-Prot
    P25021
    Related
    ENSP00000366506.2, ENST00000377291.2
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001367711.1NP_001354640.1  histamine H2 receptor isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Related
    ENSP00000489742.1, ENST00000636584.1
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001393460.1NP_001380389.1  histamine H2 receptor isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_001393461.1NP_001380390.1  histamine H2 receptor isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_160284.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010219
    Related
    ENST00000624694.2
  2. NR_171689.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010219

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    175657762..175710756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714865.3XP_006714928.1  histamine H2 receptor isoform X2

    Conserved Domains (1) summary
    pfam00001
    Location:35288
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011534549.3XP_011532851.1  histamine H2 receptor isoform X1

    See identical proteins and their annotated locations for XP_011532851.1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_017009426.2XP_016864915.1  histamine H2 receptor isoform X1

    UniProtKB/TrEMBL
    A0A1B0GTK7
    Conserved Domains (1) summary
    cd15051
    Location:19299
    7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022304.2: Suppressed sequence

    Description
    NM_022304.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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