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hdac10 histone deacetylase 10 [ Danio rerio (zebrafish) ]

Gene ID: 327253, updated on 6-Jul-2026
Official Symbol
hdac10provided by ZNC
Official Full Name
histone deacetylase 10provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5464
See related
Ensembl:ENSDARG00000086458 AllianceGenome:ZFIN:ZDB-GENE-030131-5464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55652; wu:fd19e10
Summary
Enables acetylspermidine deacetylase activity and zinc ion binding activity. Acts upstream of or within regulation of tubulin deacetylation; spermidine deacetylation; and swimming behavior. Predicted to be located in cytoplasm. Orthologous to human HDAC10 (histone deacetylase 10). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See hdac10 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (5652159..5689342)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (5015035..5033064)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain-containing protein 5A Neighboring gene von Willebrand factor A domain-containing protein 5A Neighboring gene parvin, beta Neighboring gene parvin, gamma

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Herbst-Gervasoni CJ, et al. Biochemistry, 2021 Feb 2. PMID 33449614, Free PMC Article
  2. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Herbst-Gervasoni CJ, et al. ACS Chem Biol, 2020 Aug 21. PMID 32659072, Free PMC Article
  3. Binding of N(8)-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Herbst-Gervasoni CJ, et al. Biochemistry, 2019 Dec 10. PMID 31746596, Free PMC Article
  4. Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia. Łysyganicz PK, et al. Front Cell Dev Biol, 2021. PMID 34268305, Free PMC Article
  5. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. Kaluza D, et al. EMBO J, 2011 Aug 16. PMID 21847094, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10.
    Title: X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10.
  2. The binding of ketonic substrate analogues to HDAC10 is identical to the chemistry involved in the first step of catalysis, i.e., nucleophilic attack of a Zn(2+)-bound water molecule at the scissile carbonyl group of N(8)-acetylspermidine.
    Title: Binding of N(8)-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation.
  3. HDAC10 structure and molecular function as a polyamine deacetylase has been reported.
    Title: Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acetylputrescine deacetylase activity EXP
Inferred from Experiment
more info
 PubMed 
enables acetylputrescine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables acetylspermidine deacetylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylspermidine deacetylase activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in homologous recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within swimming behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
polyamine deacetylase HDAC10
NP_956069.1
XP_073797913.1
XP_073797914.1
XP_073797915.1
XP_073797916.1
XP_073797918.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199775.1 → NP_956069.1  polyamine deacetylase HDAC10

    See identical proteins and their annotated locations for NP_956069.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044446
    UniProtKB/Swiss-Prot
    F1QCV2, Q803K0
    Related
    ENSDARP00000109870.2, ENSDART00000127600.4
    Conserved Domains (2) summary
    cd11683
    Location:20 → 356
    HDAC10; Histone deacetylase 10
    cl17011
    Location:559 → 665
    Arginase_HDAC; Arginase-like and histone-like hydrolases

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    5652159..5689342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073941817.1 → XP_073797918.1  polyamine deacetylase HDAC10 isoform X3

    UniProtKB/TrEMBL
    A0AC58IUK6

  2. XM_073941815.1 → XP_073797916.1  polyamine deacetylase HDAC10 isoform X2

    UniProtKB/Swiss-Prot
    F1QCV2, Q803K0
    UniProtKB/TrEMBL
    A0AC58IUK7, A0AC58IUK8, A0AC58IUK9

  3. XM_073941813.1 → XP_073797914.1  polyamine deacetylase HDAC10 isoform X2

    UniProtKB/Swiss-Prot
    F1QCV2, Q803K0
    UniProtKB/TrEMBL
    A0AC58IUK7, A0AC58IUK8, A0AC58IUK9

  4. XM_073941814.1 → XP_073797915.1  polyamine deacetylase HDAC10 isoform X2

    UniProtKB/Swiss-Prot
    F1QCV2, Q803K0
    UniProtKB/TrEMBL
    A0AC58IUK7, A0AC58IUK8, A0AC58IUK9

  5. XM_073941812.1 → XP_073797913.1  polyamine deacetylase HDAC10 isoform X1

    UniProtKB/Swiss-Prot
    F1QCV2, Q803K0
    UniProtKB/TrEMBL
    A0AC58IUL5

RNA

  1. XR_012399775.1 RNA Sequence

  2. XR_012399777.1 RNA Sequence

  3. XR_012399776.1 RNA Sequence

  4. XR_012399778.1 RNA Sequence

  5. XR_012399774.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1QCV2.2 GenPept UniProtKB/Swiss-Prot:F1QCV2

Gene LinkOut

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