Format

Send to:

Choose Destination

vcp valosin containing protein [ Danio rerio (zebrafish) ]

Gene ID: 327197, updated on 22-Jun-2021

Summary

Official Symbol
vcpprovided by ZNC
Official Full Name
valosin containing proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5408
See related
Ensembl:ENSDARG00000020008
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CDC48; wu:fd16d05; wu:fj63d11
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See vcp in Genome Data Viewer
Location:
chromosome: 5
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (41510420..41520582)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (40910267..40920429)
103 previous assembly Zv9 (GCF_000002035.4) 5 NC_007116.5 (43129002..43139164)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 2, like 2 Neighboring gene FA complementation group G Neighboring gene aldo-keto reductase family 1, member A1a (aldehyde reductase) Neighboring gene DnaJ heat shock protein family (Hsp40) member B5

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in ER-associated misfolded protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome maturation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in double-strand break repair ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endosome to lysosome transport via multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in interstrand cross-link repair ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle disassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to chromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in translesion synthesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in site of double-strand break ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transitional endoplasmic reticulum ATPase
Names
VCP
protein CDC48
NP_958889.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201481.1NP_958889.1  transitional endoplasmic reticulum ATPase

    See identical proteins and their annotated locations for NP_958889.1

    Status: PROVISIONAL

    Source sequence(s)
    BC050488
    UniProtKB/Swiss-Prot
    Q7ZU99
    Related
    ENSDARP00000012048.8, ENSDART00000023779.9
    Conserved Domains (6) summary
    smart01072
    Location:131191
    CDC48_2; Cell division protein 48 (CDC48) domain 2
    TIGR01243
    Location:25764
    CDC48; AAA family ATPase, CDC48 subfamily
    pfam00004
    Location:241370
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam02359
    Location:25107
    CDC48_N; Cell division protein 48 (CDC48), N-terminal domain
    pfam09336
    Location:718760
    Vps4_C; Vps4 C terminal oligomerization domain
    cl21455
    Location:452534
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    41510420..41520582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395242.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    280044..290078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center