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CG5162 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32709, updated on 4-Jan-2025

Summary

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Official Symbol
CG5162provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030828
Locus tag
Dmel_CG5162
See related
AllianceGenome:FB:FBgn0030828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5162
Summary
Enables serine hydrolase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG5162 in Genome Data Viewer
Location:
15F4-15F4; 1-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17215304..17217365)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17109337..17111398)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging. Sun X, et al. Nat Commun, 2023 Oct 6. PMID 37803019, Free PMC Article
  2. Aversive conditioning information transmission in Drosophila. Wu MS, et al. Cell Rep, 2023 Oct 31. PMID 37782557
  3. Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. Chiang YN, et al. PLoS Genet, 2016 Jun. PMID 27333054, Free PMC Article
  4. Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila. Sirot LK, et al. Mol Biol Evol, 2014 Jun. PMID 24682282, Free PMC Article
  5. Dietary Sugar Shifts Mitochondrial Metabolism and Small RNA Biogenesis in Sperm. Ramesh R, et al. Antioxid Redox Signal, 2023 Jun. PMID 36509450, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine hydrolase activity HDA PubMed 
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction HEP PubMed 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5162-PA
CG5162-PB
NP_001285367.1
NP_573202.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17215304..17217365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298438.1 → NP_001285367.1  uncharacterized protein Dmel_CG5162, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285367.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXG0, Q9VX69
    Conserved Domains (2) summary
    cd00707
    Location:99 → 365
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:94 → 369
    Lipase; Lipase

  2. NM_132974.2 → NP_573202.1  uncharacterized protein Dmel_CG5162, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXG0, Q9VX69
    Related
    FBpp0074167
    Conserved Domains (2) summary
    cd00707
    Location:99 → 365
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:94 → 369
    Lipase; Lipase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXG0 Q8SXG0
Q9VX69 Q9VX69

Gene LinkOut

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