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tecrb trans-2,3-enoyl-CoA reductase b [ Danio rerio (zebrafish) ]

Gene ID: 326954, updated on 21-Jun-2025
Official Symbol
tecrbprovided by ZNC
Official Full Name
trans-2,3-enoyl-CoA reductase bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5154
See related
Ensembl:ENSDARG00000025904 AllianceGenome:ZFIN:ZDB-GENE-030131-5154
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb250; gpsn2; sb:cb250; mg:db03b10; wu:fj63b12
Summary
Predicted to enable very-long-chain enoyl-CoA reductase activity. Predicted to be involved in sphingolipid metabolic process and very long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including digestive system; eye; forebrain; musculature system; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 14. Orthologous to human TECR (trans-2,3-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
human mouse all
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See tecrb in Genome Data Viewer
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 1 NC_133176.1 (59240781..59267769)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 1 NC_007112.7 (55752643..55779096)

Chromosome 1 - NC_133176.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E3-like Neighboring gene adhesion G protein-coupled receptor E10 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1b Neighboring gene uncharacterized LOC141375189 Neighboring gene NADH:ubiquinone oxidoreductase subunit B7 Neighboring gene zgc:136908 Neighboring gene sterile alpha motif domain containing 1b

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. Howarth DL, et al. PLoS Genet, 2014. PMID 24874946, Free PMC Article
  2. A comparative map of the zebrafish genome. Woods IG, et al. Genome Res, 2000 Dec. PMID 11116086, Free PMC Article
  3. Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Takashima S, et al. Mol Genet Metab, 2021 Jul. PMID 34016526
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables very-long-chain enoyl-CoA reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very-long-chain enoyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
trans-2,3-enoyl-CoA reductase b
Names
glycoprotein, synaptic 2
tecr
NP_958456.1
XP_021335340.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201299.1 → NP_958456.1  trans-2,3-enoyl-CoA reductase b

    See identical proteins and their annotated locations for NP_958456.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053209
    UniProtKB/TrEMBL
    B2GNT0, F6NM58, Q7T390
    Related
    ENSDARP00000098524.2, ENSDART00000108838.4
    Conserved Domains (2) summary
    cd01801
    Location:6 → 81
    Tsc13_N; Ubiquitin-like domain of Tsc13
    cl21511
    Location:155 → 308
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133176.1 Reference GRCz12tu Primary Assembly

    Range
    59240781..59267769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479665.3 → XP_021335340.1  trans-2,3-enoyl-CoA reductase b isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLQ8
    Conserved Domains (1) summary
    PLN02560
    Location:63 → 345
    PLN02560; enoyl-CoA reductase

RNA

  1. XR_012386782.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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