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eef2b eukaryotic translation elongation factor 2b [ Danio rerio (zebrafish) ]

Gene ID: 326929, updated on 2-Nov-2024

Summary

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Official Symbol
eef2bprovided by ZNC
Official Full Name
eukaryotic translation elongation factor 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5128
See related
Ensembl:ENSDARG00000100371 AllianceGenome:ZFIN:ZDB-GENE-030131-5128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EEF2; eef2l; fe49h02; zgc:63584; wu:fe49h02
Summary
Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Acts upstream of or within cellular response to xenobiotic stimulus and chordate embryonic development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including epidermis; immature eye; nervous system; tail bud; and trunk. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See eef2b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (57149033..57174950)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (56935811..56961728)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 42 Neighboring gene microRNA mir-7148 Neighboring gene armadillo repeat containing 6 Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene transfer RNA threonine (anticodon AGU)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning, expression and functional study of translation elongation factor 2 (EF-2) in zebrafish. Zhang SH, et al. Int J Dev Biol, 2006. PMID 16525935
  2. Cloning and expression of translation elongation factor 2 (EF-2) in zebrafish. Zhang SH, et al. DNA Seq, 2008 Feb. PMID 18300156
  3. Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. Hurem S, et al. PLoS One, 2017. PMID 28628668, Free PMC Article
  4. A molecular network of conserved factors keeps ribosomes dormant in the egg. Leesch F, et al. Nature, 2023 Jan. PMID 36653451, Free PMC Article
  5. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EF-2 is a developmentally regulated gene and might play important roles during the early development of zebrafish embryos.
    Title: Cloning, expression and functional study of translation elongation factor 2 (EF-2) in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC63584

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
elongation factor 2b
Names
EF-2
eukaryotic translation elongation factor 2, like
NP_956752.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200458.2 → NP_956752.2  elongation factor 2b

    See identical proteins and their annotated locations for NP_956752.2

    Status: PROVISIONAL

    Source sequence(s)
    AY391422
    UniProtKB/Swiss-Prot
    A0A0R4IA71, Q6P3J5, Q6TNU5
    Related
    ENSDARP00000131100.1, ENSDART00000168497.2
    Conserved Domains (6) summary
    cd01885
    Location:20 → 233
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:574 → 746
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:742 → 821
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:1 → 858
    PTZ00416; elongation factor 2; Provisional
    cd03700
    Location:394 → 488
    EF2_snRNP_like_II; Domain II of elongation factor 2 and C-terminal domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein
    cd16261
    Location:503 → 574
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    57149033..57174950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3J5.1 GenPept UniProtKB/Swiss-Prot:Q6P3J5

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