Ubr1 Ubr1 ubiquitin ligase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ubr1provided by FlyBase
Official Full Name: Ubr1 ubiquitin ligaseprovided by FlyBase
Primary source: FLYBASE:FBgn0030809
Locus tag: Dmel_CG9086
See related: AllianceGenome:FB:FBgn0030809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9086; Dmel\CG9086; ubr1; UBR1; UBR1/2
Summary: Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in adult head. Used to study metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome and cardiovascular system disease. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1) and UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16956232..16968679, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16850265..16862712, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain